High mass resolution breath analysis using secondary electrospray ionization mass spectrometry assisted by an ion funnel

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Author(s) Meier, Lukas, Berchtold, Christian, Schmid, Stefan, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title High mass resolution breath analysis using secondary electrospray ionization mass spectrometry assisted by an ion funnel
Author(s) Meier, Lukas
Berchtold, Christian
Schmid, Stefan
Zenobi, Renato
Journal or Series Title Journal of mass spectrometry
Volume Number 47
Issue Number 12
Start Page 1571
End Page 1575
ISSN 1076-5174
1076-5164
1096-9888
Publisher Wiley
Publication Place Chichester
Publication Date 2012-12
Keyword(s) Secondary electrospray ionization
Ion funnel
Breath analysis
Online mass
Spectrometry
FTICR
Abstract In this study, we used secondary electrospray ionization mass spectrometry assisted by an ion funnel (IF) operating at ambient pressure to find compounds in the mass range of 100–500 m/z in online breath fingerprinting experiments. In low-resolution experiments conducted on an ion trap instrument, we found that pyridine is present in breath of individuals long after drinking coffee. In high-resolution experiments conducted on a Fourier transform ion cyclotron resonance, we found more than 30 compounds in the mass range of 100–500 m/z in analogous online breath experiments. More than a third of these compounds have molecular weights above 200 Daltons and have not been mentioned in previous studies. In low-resolution experiments as well as experiments without the IF, these compounds could not be detected.
DOI 10.1002/jms.3118
Additional Notes Manuscript received 6 August 2012, Manuscript revised 23 September 2012, Manuscript accepted 3 October 2012, Article first published online 6 December 2012
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
Organisational Unit(s)
NEBIS System Number 001410098
Source Database ID FORM-1358157187
WOS-000312943400006
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@article{Mr2012,
  author = "Meier, Lukas and Berchtold, Christian and Schmid, Stefan and Zenobi, Renato",
  title = "{H}igh mass resolution breath analysis using secondary electrospray ionization mass spectrometry assisted by an ion funnel",
  journal = "Journal of mass spectrometry",
  year = 2012,
  volume = "47",
  number = "12",
  pages = "1571--1575",
  month = dec,
}


E-Citations record created: Mon, 14 Jan 2013, 09:53:26 CET