Positive and negative analyte ion yield in matrix-assisted laser desorption/ionization

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Author(s) Dashtiev, Maxim, Waefler, Esther, Roehling, Ulrich, Gorshkov, Michael, Hillenkamp, Franz, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Positive and negative analyte ion yield in matrix-assisted laser desorption/ionization
Author(s) Dashtiev, Maxim
Waefler, Esther
Roehling, Ulrich
Gorshkov, Michael
Hillenkamp, Franz
Zenobi, Renato
Journal or Series Title International journal of mass spectrometry
Volume Number 268
Issue Number 2-3
Start Page 122
End Page 130
ISSN 1387-3806
Publisher Elsevier Science
Publication Place Amsterdam, NL
Publication Date 2007-12
Keyword(s) MALDI
Ion yield
Ionization mechanism
Abstract The ratios of positive to negative analyte ion yields for matrix-assisted laser desorption ionization were studied for fibrinopeptide A, angiotensin I and bradykinin in combination with six matrices (CHCA, DHB, 4-NA, ATT, ANP, 5-AQ). The selection of these particular compounds was based on their acid/base properties. The measurements were carried out on two different time-of-flight instruments, one of which was equipped with a charge collection detector. The findings are: (i) for a desorption from a non-metallic substrate the total positive/negative ion yield ratio is approximate to 1. (ii) The analyte positive/negative ion yield is strongly dependent on many factors, and generally scatters a lot. More acidic matfices were found to produce a positive/negative analyte ion yield ratio > 1, whereas for basic matrices, the ratio was <= 1. (iii) For selected matrices, the positive/negative analyte ion yield ratio follows the acidibase properties of the analyte. (iv) Clear indications for a significant contribution of clusters as carriers of the total charge in MALDI were obtained from the data. (C) 2007 Elsevier B.V. All rights reserved.
DOI 10.1016/j.ijms.2007.07.001
Document Type Article
Publication Status Published
Language English
NEBIS System Number 000024690
Source Database ID WOS-000251467500006
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  author = "Dashtiev, Maxim and Waefler, Esther and Roehling, Ulrich and Gorshkov, Michael and Hillenkamp, Franz and Zenobi, Renato",
  title = "{P}ositive and negative analyte ion yield in matrix-assisted laser desorption/ionization",
  journal = "International journal of mass spectrometry",
  year = 2007,
  volume = "268",
  number = "2-3",
  pages = "122--130",
  month = dec,

E-Citations record created: Wed, 12 Dec 2012, 07:37:02 CET