Thermodynamic control of final ion distributions in MALDI: Iin-plume proton transfer reactions

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Author(s) Breuker, Kathrin, Knochenmuss, Richard D., Zhang, Juan, Stortelder, Aike, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Thermodynamic control of final ion distributions in MALDI: Iin-plume proton transfer reactions
Author(s) Breuker, Kathrin
Knochenmuss, Richard D.
Zhang, Juan
Stortelder, Aike
Zenobi, Renato
Journal or Series Title International journal of mass spectrometry
Volume Number 226
Issue Number 1
Start Page 211
End Page 222
ISSN 1387-3806
Publisher Elsevier
Publication Place Amsterdam
Publication Date 2003-03-15
Keyword(s) MALDI
Gas-phase basicity
Proton transfer reactions
Abstract Gas-phase thermochemical data on matrix-assisted laser desorption/ionization (MALDI) matrix species were used to calculate the energetics of possible proton transfer reactions. These were investigated for the MALDI matrices 2,4,6-trihydroxy-acetophenone and sinapic acid, with the tripeptide glycyl-glycyl-histidine as analyte. MALDI proton transfer product ion distributions were found to be predicted by the energetics of possible secondary ion-molecule reactions, at all laser fluences sufficient to generate a dense plume. Near the ion generation fluence threshold, the mass spectra deviate from the thermodynamic predictions. This shows that the MALDI plume exhibits both thermodynamically and kinetically controlled regimes, depending on desorption conditions. Possible thermal ground state proton transfer primary ionization pathways were also considered, and found to be inconsistent with the data.
DOI 10.1016/S1387-3806(02)00965-X
Additional Notes Received 26 July 2001, Accepted 12 August 2002, Published online 17 October 2002
Document Type Article
Publication Status Published
Language English
NEBIS System Number 000024690
Source Database ID WOS-000181270000014
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  author = "Breuker, Kathrin and Knochenmuss, Richard D. and Zhang, Juan and Stortelder, Aike and Zenobi, Renato",
  title = "{T}hermodynamic control of final ion distributions in {M}{A}{L}{D}{I}: {I}in-plume proton transfer reactions",
  journal = "International journal of mass spectrometry",
  year = 2003,
  volume = "226",
  number = "1",
  pages = "211--222",
  month = mar,

E-Citations record created: Fri, 09 Nov 2012, 07:10:10 CET