Sequential loss of myelin proteins during Wallerian degeneration in the rat spinal cord

Metadata Label Value
Author(s) Pretsch, Ernö, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
Full Text Search SFX for a Full-Text version of this document
Import to Mendeley

Detailed Information

Metadata Field Content
Title Sequential loss of myelin proteins during Wallerian degeneration in the rat spinal cord
Author(s) Pretsch, Ernö
Zenobi, Renato
Journal or Series Title Glia
Volume Number 42
Issue Number 4
Start Page 424
End Page 432
ISSN 0894-1491
Publisher Wiley-Liss
Publication Place Hoboken, NJ
Publication Date 2003-05
Keyword(s) Myelin associated glycoprotein
Abstract Axotomy of nerve fibers leads to the subsequent degeneration of their distal part, a process termed Wallerian degeneration (WD). While WD in the peripheral nervous system is usually followed by regeneration of the lesioned axons, central nervous system (CNS) neurons are generally unable to regrow: In this study, we investigated the process of WD in the dorsal columns of the rat spinal cord rostral to a mid-thoracic lesion. We confirm earlier studies describing a very delayed microglial and an early and sustained astroglial reaction finally leading to scar formation. Interestingly, we found a differential time course in the loss of myelin proteins depending on their location. Proteins situated on the periaxonal myelin membrane such as myelin associated glycoprotein disappeared early, within a few days after lesion, concomitantly with cytoskeletal axonal proteins, whereas compact myelin and outer myelin membrane proteins such as MBP and Nogo-A remained for long intervals in the degenerating tracts. Two distinct mechanisms are probably responsible for this difference: processes of protein destruction emanating from and initially probably located in the axon act on a time scale of 1-3 days. In contrast, the bulk of myelin destruction is due to phagocytosis known to be slow, prolonged, and inefficient, in the CNS. These results may also have implications for future intervention strategies aiming at enhancing CNS regeneration.
DOI 10.1002/glia.10220
Additional Notes Manuscript received 27 December 2002, Manuscript accepted 3 January 2003, Article first published online 10 April 2003
Document Type Article
Publication Status Published
Language English
NEBIS System Number 000975565
Source Database ID WOS-000183272100012
Description File Name MIME Type Size
No details could be found
There are no links available for this record.
This record has not been viewed during this period

  author = "Pretsch, Ern{\"{o}} and Zenobi, Renato",
  title = "{S}equential loss of myelin proteins during {W}allerian degeneration in the rat spinal cord",
  journal = "Glia",
  year = 2003,
  volume = "42",
  number = "4",
  pages = "424--432",
  month = may,

E-Citations record created: Mon, 22 Oct 2012, 16:26:11 CET