Production and fragmentation of multiply charged ions in 'electron-free' matrix-assisted laser desorption/ionization

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Author(s) Frankevich, Vladimir, Zhang, Juan, Dashtiev, Maxim, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Production and fragmentation of multiply charged ions in 'electron-free' matrix-assisted laser desorption/ionization
Author(s) Frankevich, Vladimir
Zhang, Juan
Dashtiev, Maxim
Zenobi, Renato
Journal or Series Title Rapid communications in mass spectrometry
Volume Number 17
Issue Number 20
Start Page 2343
End Page 2348
ISSN 0951-4198
1097-0231
Publisher Wiley
Publication Place London
Publication Date 2003-10
Abstract An unusually large fraction of multiply charged ions is observed in 'electron-free' matrix-assisted laser desorption/ionization (MALDI). Here we investigate how the yield of multiply charged ions depends on experimental parameters in MALDI. It is found to increase if measures are taken to limit the number of electrons in the plume, for example, by using non-metallic MALDI targets or low laser pulse energies. The ionization energy of the matrix is another important parameter that affects the yield of multiply charged ions: matrices with high ionization energies lead to greater intensities of multiply charged ions. It is furthermore proposed that some of the fragment ions observed in MALDI are due to reactions of analyte with electrons in the plume. The possibility of electron capture dissociation of multiply charged ions produced by MALDI is shown.
DOI 10.1002/rcm.1194
Additional Notes Article first published online 19 September 2003, Manuscript revised 18 August 2003, Manuscript accepted 18 August 2003, Manuscript received 2 June 2003
Document Type Article
Publication Status Published
Language English
NEBIS System Number 000038989
Source Database ID WOS-000185867500016
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@article{Frnkvch2003,
  author = "Frankevich, Vladimir and Zhang, Juan and Dashtiev, Maxim and Zenobi, Renato",
  title = "{P}roduction and fragmentation of multiply charged ions in 'electron-free' matrix-assisted laser desorption/ionization",
  journal = "Rapid communications in mass spectrometry",
  year = 2003,
  volume = "17",
  number = "20",
  pages = "2343--2348",
  month = oct,
}


E-Citations record created: Wed, 05 Sep 2012, 08:38:32 CET