On-line atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry

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Author(s) Daniel, Jürg M., Ehala, Sille, Friess, Sebastian D., Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title On-line atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry
Author(s) Daniel, Jürg M.
Ehala, Sille
Friess, Sebastian D.
Zenobi, Renato
Journal or Series Title The analyst
Volume Number 129
Issue Number 7
Start Page 574
End Page 578
ISSN 0003-2654
1364-5528
Publisher Royal Society of Chemistry
Publication Place Cambridge
Publication Date 2004
Abstract A new technique is presented for the coupling of atmospheric pressure matrix-assisted laser desorption/ionization (AP-MALDI) mass spectrometry with liquid delivery systems. Mass measurements of polymers and peptides are demonstrated using a co-dissolved matrix, e.g. alpha-cyano-4-hydroxycinnamic acid ( HCCA). Improvements in terms of sensitivity are achieved by optimizing the shape und control of the exit capillary and by using a laser ( 355 nm) at a 1 kHz repetition rate. Two calibration experiments promise a good applicability of the presented coupling method for quantitative measurements. The limit of detection achieved so far is 500 nM for peptides in methanol solution containing 25 mM HCCA.
DOI 10.1039/b404178j
Additional Notes Received 19 March 2004, Accepted 30 April 2004, Published online 7 June 2004
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
Organisational Unit(s)
NEBIS System Number 000023536
Source Database ID WOS-000222202300004
PP-9446
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@article{Dnl2004,
  author = "Daniel, J{\"{u}}rg M. and Ehala, Sille and Friess, Sebastian D. and Zenobi, Renato",
  title = "{O}n-line atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry",
  journal = "The analyst",
  year = 2004,
  volume = "129",
  number = "7",
  pages = "574--578",
}


E-Citations record created: Thu, 05 Jul 2012, 08:11:24 CET