Matrix-dependent cationization in MALDI mass spectrometry

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Author(s) Zhang, Juan, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Matrix-dependent cationization in MALDI mass spectrometry
Author(s) Zhang, Juan
Zenobi, Renato
Journal or Series Title Journal of mass spectrometry
Volume Number 39
Issue Number 7
Start Page 808
End Page 816
ISSN 1076-5174
Publisher Wiley
Publication Place Chichester
Publication Date 2004-07
Keyword(s) Matrix-assisted laser desorption/ionization
Gas phase
Alkali metal ion
Gas-phase cation basicities
Gas-phase cation transfer reaction
Matrix suppression
Abstract The matrix dependence in cationization processes, the competition between cationization and protonation and the question of whether gas-phase cation transfer or attachment of free cations dominates in matrix-assisted laser desorption/ionization mass spectrometry were studied. Two different sample preparation methods were employed, the dried-droplet sample preparation and a mixture of solid matrix, analyte and salt. The latter ensures that the formation of cation adducts takes place in the gas phase. By monitoring the suppression of matrix signals for different matrices, it was found that matrices with high gas-phase metal ion binding energies require high analyte concentrations for matrix suppression to occur. By comparing the mass spectra obtained using sinapinic acid or sinapinic methyl ester as a matrix, a correlation between cationization and deprotonation of matrix molecules was found. It is also demonstrated that attachment of free gas-phase cations, rather than cation transfer from the cationized matrix, is the predominant process in cationization.
DOI 10.1002/jms.657
Additional Notes Article first published online 14 July 2004, Manuscript accepted 3 May 2004, Manuscript received 7 November 2003
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
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NEBIS System Number 001410098
Source Database ID WOS-000222949800011
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  author = "Zhang, Juan and Zenobi, Renato",
  title = "{M}atrix-dependent cationization in {M}{A}{L}{D}{I} mass spectrometry",
  journal = "Journal of mass spectrometry",
  year = 2004,
  volume = "39",
  number = "7",
  pages = "808--816",
  month = jul,

E-Citations record created: Wed, 27 Jun 2012, 16:07:26 CET