Sensitive detection of drug vapors using an ion funnel interface for secondary electrospray ionization mass spectrometry

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Author(s) Meier, Lukas, Berchtold, Christian, Schmid, Stefan, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Sensitive detection of drug vapors using an ion funnel interface for secondary electrospray ionization mass spectrometry
Author(s) Meier, Lukas
Berchtold, Christian
Schmid, Stefan
Zenobi, Renato
Journal or Series Title Journal of mass spectrometry
Volume Number 47
Issue Number 5
Start Page 555
End Page 559
ISSN 1076-5174
1076-5164
1096-9888
Publisher Wiley
Publication Place Chichester
Publication Date 2012-05
Keyword(s) Secondary electrospray ionization
Ion funnel
Biological samples
Surface analysis
Online mass spectrometry
Abstract In this study, we use an ion funnel (IF) at ambient pressure to enhance the sensitivity of secondary electrospray ionization (SESI). Atenolol, salbutamol and cocaine as test compounds are delivered to the SESI interface in the gas phase and are charged with three nano electrosprays. In our experiments, we show that the compounds can be detected at concentrations in the low pptv range, which is an increase of two orders of magnitude compared with the results without the IF. With a standard SESI interface, the compounds could not be detected at all. With the use of the SESI IF interface for the headspace analysis of bananas and limes, we can detect many more compounds and at higher intensities than with a standard SESI interface.
DOI 10.1002/jms.2982
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
Organisational Unit(s)
NEBIS System Number 001410098
Source Database ID WOS-000303439700003
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@article{Mr2012,
  author = "Meier, Lukas and Berchtold, Christian and Schmid, Stefan and Zenobi, Renato",
  title = "{S}ensitive detection of drug vapors using an ion funnel interface for secondary electrospray ionization mass spectrometry",
  journal = "Journal of mass spectrometry",
  year = 2012,
  volume = "47",
  number = "5",
  pages = "555--559",
  month = may,
}


E-Citations record created: Tue, 29 May 2012, 07:35:00 CET