Extractive Electrospray Ionization Mass Spectrometry Enhanced Sensitivity Using an Ion Funnel

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Author(s) Meier, Lukas, Berchtold, Christian, Schmid, Stefan, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Extractive Electrospray Ionization Mass Spectrometry Enhanced Sensitivity Using an Ion Funnel
Author(s) Meier, Lukas
Berchtold, Christian
Schmid, Stefan
Zenobi, Renato
Journal or Series Title Analytical chemistry
Volume Number 84
Issue Number 4
Start Page 2076
End Page 2080
ISSN 0003-2700
Publisher American Chemical Society
Publication Place Washington, D.C.
Publication Date 2012-02
Abstract Electrodynamic ion funnel interfaces for electrospray ionization (ESI) have shown to enhance the sensitivity of measurements by more than 2 orders of magnitude in the intermediate pressure region of the instrument (1-30 Torr). In this study, we use an ion funnel at ambient pressure to enhance the sensitivity of extractive electrospray ionization (EESI) by spraying directly into the ion funnel. EESI is a powerful ionization technique that is capable of handling complex matrixes that may contain dozens of compounds. Our results using atenolol, salbutamol, and cocaine as test compounds show that we can improve the limit of detection for these compounds by more than 3 orders of magnitude compared to standard EESI experiments.
DOI 10.1021/ac203022x
Additional Notes Received 14 November 2011, Accepted 5 January 2012, Published 5 January 2012
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
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NEBIS System Number 000005465
Source Database ID WOS-000300470800042
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  author = "Meier, Lukas and Berchtold, Christian and Schmid, Stefan and Zenobi, Renato",
  title = "{E}xtractive {E}lectrospray {I}onization {M}ass {S}pectrometry {E}nhanced {S}ensitivity {U}sing an {I}on {F}unnel",
  journal = "Analytical chemistry",
  year = 2012,
  volume = "84",
  number = "4",
  pages = "2076--2080",
  month = feb,

E-Citations record created: Fri, 13 Apr 2012, 07:17:28 CET