Contribution of liquid-phase and gas-phase ionization in extractive electrospray ionization mass spectrometry of primary amines

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Author(s) Meier, Lukas, Schmid, Stefan, Berchtold, Christian, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Contribution of liquid-phase and gas-phase ionization in extractive electrospray ionization mass spectrometry of primary amines
Author(s) Meier, Lukas
Schmid, Stefan
Berchtold, Christian
Zenobi, Renato
Journal or Series Title European journal of mass spectrometry
Volume Number 17
Issue Number 4
Start Page 345
End Page 351
ISSN 1751-6838
1469-0667
1356-1049
Publisher IM Publications
Publication Place Chichester
Publication Date 2011
Keyword(s) Electrospray Ionization (ESI)
Secondary electrospray ionization (SESI)
Extractive electrospray ionization (EESI)
Ionization mechanism
Abstract In this study, we investigated how binary mixtures of compounds influence each other's signal intensity in electrospray ionization (ESI), extractive electrospray ionization (EESI) and secondary electrospray ionization (SESI) experiments. The experiments were conducted using a series of homologous primary amines (from 1-butyl to 1-decylamine). In every experiment, two of the amines were present, and all 21 possible combinations were measured with EESI, ESI and SESI as ionization sources. Except for the volatility, which decreases with increasing molecular weight, the physico–chemical properties of the amines are very similar, so that the intensity ratio obtained in each experiment provides information about discrimination effects occurring during the ionization process. The results show that for the relatively volatile compounds investigated, the EESI ionization mechanism resembles the SESI-like gas-phase charge transfer more than ESI-like analyte ionization in solution. In addition, almost no discrimination effects were observed in the spectra obtained in EESI experiments. Quantitative EESI experiments with nonylamine as internal standard showed that EESI is capable of providing both more accurate and more precise results than SESI and ESI.
DOI 10.1255/ejms.1146
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
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Source Database ID WOS-000296931000004
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@article{Mr2011,
  author = "Meier, Lukas and Schmid, Stefan and Berchtold, Christian and Zenobi, Renato",
  title = "{C}ontribution of liquid-phase and gas-phase ionization in extractive electrospray ionization mass spectrometry of primary amines",
  journal = "European journal of mass spectrometry",
  year = 2011,
  volume = "17",
  number = "4",
  pages = "345--351",
}


E-Citations record created: Mon, 05 Dec 2011, 08:38:36 CET