Nanoscale chemical imaging of segregated lipid domains using tip-enhanced Raman spectroscopy

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Author(s) Opilik, Lothar, Bauer, Thomas, Schmid, Thomas, Stadler, Johannes, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Nanoscale chemical imaging of segregated lipid domains using tip-enhanced Raman spectroscopy
Author(s) Opilik, Lothar
Bauer, Thomas
Schmid, Thomas
Stadler, Johannes
Zenobi, Renato
Journal or Series Title Physical chemistry, chemical physics
Volume Number 13
Issue Number 21
Start Page 9978
End Page 9981
ISSN 1463-9076
Publisher The Royal Society of Chemistry
Publication Place Cambridge
Publication Date 2011
Abstract Lipid domains in supported lipid layers serve as a popular model to gain insight into the processes associated with the compartmentalization of biological membranes into so-called lipid rafts. In this paper, we present reproducible tip-enhanced Raman spectra originating from a very small number of molecules in a lipid monolayer on a gold surface, probed by the apex of a nanometer-sized silver tip. For the first time, we show large (128 x 128 pixels), high-resolution (<50 nm) tip-enhanced Raman images of binary lipid mixtures with full spectral information at each pixel.
DOI 10.1039/c0cp02832k
Additional Notes Received 9 December 2010, Accepted 9 March 2011, First published on the web 23 March 2011
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
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NEBIS System Number 002005974
Source Database ID WOS-000290732000007
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  author = "Opilik, Lothar and Bauer, Thomas and Schmid, Thomas and Stadler, Johannes and Zenobi, Renato",
  title = "{N}anoscale chemical imaging of segregated lipid domains using tip-enhanced {R}aman spectroscopy",
  journal = "Physical chemistry, chemical physics",
  year = 2011,
  volume = "13",
  number = "21",
  pages = "9978--9981",

E-Citations record created: Mon, 06 Jun 2011, 06:16:30 CET