Lab-on-a-plate

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Author(s) Urban, Pawel L., Amantonico, Andrea, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Metadata Field Content
Title Lab-on-a-plate
Subtitle Extending the functionality of MALDI-MS and LDI-MS targets
Author(s) Urban, Pawel L.
Amantonico, Andrea
Zenobi, Renato
Journal or Series Title Mass spectrometry reviews
Volume Number 30
Issue Number 3
Start Page 435
End Page 478
ISSN 0277-7037
1098-2787
Publisher Wiley
Publication Place New York, NY, USA
Publication Date 2011
Keyword(s) High-throughput analysis
MALDI
microfluidics
on-plate sample treatment
sample preparation
Abstract We review the literature that describes how (matrix-assisted) laser desorption/ionization (MA) LDI target plates can be used not only as sample supports, but beyond that: as functional parts of analytical protocols that incorporate detection by MALDI-MS or matrix-free LDI-MS. Numerous steps of analytical procedures can be performed directly on the (MA) LDI target plates prior to the ionization of analytes in the ion source of a mass spectrometer. These include homogenization, preconcentration, amplification, purification, extraction, digestion, derivatization, synthesis, separation, detection with complementary techniques, data storage, or other steps. Therefore, we consider it helpful to define the "lab-on-a-plate" as a format for carrying out extensive sample treatment as well as bioassays directly on (MA) LDI target plates. This review introduces the lab-on-plate approach and illustrates it with the aid of relevant examples from the scientific and patent literature.
DOI 10.1002/mas.20288
Additional Notes Published online 20 January 2011 in Wiley Online Library
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
Organisational Unit(s)
NEBIS System Number 000015310
Source Database ID WOS-000289532100005
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@article{rbn2011,
  author = "Urban, Pawel L. and Amantonico, Andrea and Zenobi, Renato",
  title = "{L}ab-on-a-plate: {E}xtending the functionality of {M}{A}{L}{D}{I}-{M}{S} and {L}{D}{I}-{M}{S} targets",
  journal = "Mass spectrometry reviews",
  year = 2011,
  volume = "30",
  number = "3",
  pages = "435--478",
}


E-Citations record created: Mon, 02 May 2011, 06:56:35 CET