Analysis of megadalton ions using cryodetection MALDI time-of-flight mass spectrometry

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Author(s) Wenzel, Ryan J., Matter, Urs, Schultheis, Lothar, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Analysis of megadalton ions using cryodetection MALDI time-of-flight mass spectrometry
Author(s) Wenzel, Ryan J.
Matter, Urs
Schultheis, Lothar
Zenobi, Renato
Journal or Series Title Analytical chemistry
Volume Number 77
Issue Number 14
Start Page 4329
End Page 4337
ISSN 0003-2700
Publisher American Chemical Society
Publication Place Washington D.C.
Publication Date 2005-07
Abstract Presented are initial results from the first commercially available matrix-assisted laser desorption/ionization time-of-flight mass spectrometer specifically designed for the sensitive detection of very high mass ions (macromizer, Comet AG). This new instrument utilizes a 16-element superconducting tunnel junction detector coupled with a fully adjustable gimbal-mounted ion source/focusing region that allows unparalleled sensitivity for detection of singly charged high molecular weight ions. Using this new technology, the singly charged ions in the megadalton region are detected from immunoglobulin M and von Willebrand factor proteins. This detector technology also measures the kinetic energy of the particles impacting the detector, which can be correlated to the charge of the particles. Immunoglobulin G and streptavidin were used to demonstrate the ability of the macromizer instrument to detect high-mass ions and to discern the charge state of the ions.
DOI 10.1021/ac0482054
Additional Notes Received for review 3 December 2004, Accepted 27 April 2005, Published online 27 May 2005
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
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NEBIS System Number 000005465
Source Database ID WOS-000230530300006
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  author = "Wenzel, Ryan J. and Matter, Urs and Schultheis, Lothar and Zenobi, Renato",
  title = "{A}nalysis of megadalton ions using cryodetection {M}{A}{L}{D}{I} time-of-flight mass spectrometry",
  journal = "Analytical chemistry",
  year = 2005,
  volume = "77",
  number = "14",
  pages = "4329--4337",
  month = jul,

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