Atmospheric Pressure Sampling for Laser Ablation Based Nanoscale Imaging Mass Spectrometry

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Author(s) Zhu, Liang, Stadler, Johannes, Schmitz, Thomas A., Krumeich, Frank, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Atmospheric Pressure Sampling for Laser Ablation Based Nanoscale Imaging Mass Spectrometry
Subtitle Ions or Neutrals?
Author(s) Zhu, Liang
Stadler, Johannes
Schmitz, Thomas A.
Krumeich, Frank
Zenobi, Renato
Journal or Series Title The journal of physical chemistry. C, Nanomaterials, interfaces, hard matter
Volume Number 115
Issue Number 4
Start Page 1006
End Page 1013
ISSN 1932-7447
1932-7455
Publisher American Chemical Society
Publication Place Washington, DC
Publication Date 2011-02
Abstract Although the ratio of neutrals-to-ions in a typical laser ablation event was reported to be on the order of 1000 or greater, most imaging mass spectrometry (IMS) studies collect the minor ionic component instead of the abundant neutrals for subsequent mass analysis. In this report, we present a fundamentally different strategy, sampling neutrals from atmospheric pressure laser ablation into the vacuum of the mass spectrometer, followed by postionization, and mass spectrometric analysis. We compare its overall sampling efficiency (transfer efficiency + ionization efficiency) with that of ion sampling. The products from many single ablation events (creating a crater of 1 μm in diameter each) were deposited on a collection plate placed on the vacuum side of the sampling capillary. The sample surface and the collection plate were carefully examined both prior to and after laser ablation with scanning electron microscopy (SEM) and scanning probe microscopy (SPM). Volumetric measurements gave an estimate of the sampling efficiency of (1 ± 0.7) × 10−4 overall. It was found that with a proper collection geometry, ablated neutral molecules can be efficiently directed to the inlet of the sampling capillary: several % are available for further MS analysis. We observed that the fraction of the ablated mass that leaves the sample in the form of particles was not sampled into the vacuum but was instead deposited between the ablation site and the capillary inlet. By comparing our results with those of other IMS techniques using ion sampling, we conclude that the overall sampling efficiencies are similar. Advantages provided by the neutral sampling approach include a large amount of analyte available for collection, the potential for improving the ionization efficiency, and the elimination of sample pretreatment steps.
DOI 10.1021/jp105178q
Additional Notes Received 6 June 2010, Revised 25 August 2010, Published online 23 September 2010
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03306
03430
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NEBIS System Number 005283485
Source Database ID FORM-1295618131
WOS-000286639400018
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@article{Zh2011,
  author = "Zhu, Liang and Stadler, Johannes and Schmitz, Thomas A. and Krumeich, Frank and Zenobi, Renato",
  title = "{A}tmospheric {P}ressure {S}ampling for {L}aser {A}blation {B}ased {N}anoscale {I}maging {M}ass {S}pectrometry: {I}ons or {N}eutrals?",
  journal = "The journal of physical chemistry. C, Nanomaterials, interfaces, hard matter",
  year = 2011,
  volume = "115",
  number = "4",
  pages = "1006--1013",
  month = feb,
}


E-Citations record created: Fri, 21 Jan 2011, 13:56:17 CET