Engineering the Extracellular Environment

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Author(s) Guillaume-Gentil, Orane, Semenov, Oleg, Sala Roca, Ana, Groth, Thomas, Zahn, Raphael, Vörös, Janos, Zenobi-Wong, Marcy
Publication Type Journal Items, Publication Status: Published
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Title Engineering the Extracellular Environment
Subtitle Strategies for Building 2D and 3D Cellular Structures
Author(s) Guillaume-Gentil, Orane
Semenov, Oleg
Sala Roca, Ana
Groth, Thomas
Zahn, Raphael
Vörös, Janos
Zenobi-Wong, Marcy
Journal or Series Title Advanced materials
Volume Number 22
Issue Number 48
Start Page 5443
End Page 5462
ISSN 0935-9648
Publisher Wiley-VCH
Publication Place Weinheim
Publication Date 2010-12
Keyword(s) Extracellular matrix
Self assembled monolayers
Polyelectrolyte multilayers
Cell sheet engineering
cell patterning
Abstract Cell fate is regulated by extracellular environmental signals. Receptor specific interaction of the cell with proteins, glycans, soluble factors as well as neighboring cells can steer cells towards proliferation, differentiation, apoptosis or migration. In this review, approaches to build cellular structures by engineering aspects of the extracellular environment are described. These methods include non-specific modifications to control the wettability and stiffness of surfaces using self-assembled monolayers (SAMs) and polyelectrolyte multilayers (PEMs) as well as methods where the temporal activation and spatial distribution of adhesion ligands is controlled. Building on these techniques, construction of two-dimensional cell sheets using temperature sensitive polymers or electrochemical dissolution is described together with current applications of these grafts in the clinical arena. Finally, methods to pattern cells in three-dimensions as well as to functionalize the 3D environment with biologic motifs take us one step closer to being able to engineer multicellular tissues and organs.
DOI 10.1002/adma.201001747
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03741
Organisational Unit(s)
NEBIS System Number 000504408
Source Database ID FORM-1295442580
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  author = "Guillaume-Gentil, Orane and Semenov, Oleg and Sala Roca, Ana and Groth, Thomas and Zahn, Raphael and V{\"{o}}r{\"{o}}s, Janos and Zenobi-Wong, Marcy",
  title = "{E}ngineering the {E}xtracellular {E}nvironment: {S}trategies for {B}uilding 2{D} and 3{D} {C}ellular {S}tructures",
  journal = "Advanced materials",
  year = 2010,
  volume = "22",
  number = "48",
  pages = "5443--5462",
  month = dec,

E-Citations record created: Wed, 19 Jan 2011, 13:09:48 CET