Evaluation of Extractive Electrospray Ionization and Atmospheric Pressure Chemical Ionization for the Detection of Narcotics in Breath

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Author(s) Berchtold, Christian, Meier, Lukas, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Evaluation of Extractive Electrospray Ionization and Atmospheric Pressure Chemical Ionization for the Detection of Narcotics in Breath
Author(s) Berchtold, Christian
Meier, Lukas
Zenobi, Renato
Journal or Series Title International journal of mass spectrometry
Volume Number 299
Issue Number 2-3
Start Page 145
End Page 150
ISSN 1387-3806
1873-2798
Publisher Elsevier
Publication Place Amsterdam
Publication Date 2011-01
Keyword(s) Extractive electrospray ionization
Atmospheric pressure chemical ionization
Breath analysis
Narcotic
Abstract Diagnosis by online breath analysis using mass spectrometry is challenging because of the low concentrations of pertinent compounds in breath. Here we investigate extractive electrospray ionization and atmospheric pressure chemical ionization for the detection of narcotics in breath. The limit of detection was evaluated for morphine, fentanyl, norfentanyl, naloxone, cocaine, γ-hydroxybutyrolactone (GBL), and nicotine. They were found to be in the low fmol/s range, depending on the ionization system used. Data was obtained on four different mass spectrometers: A quadrupole time-of-fight instrument, a 3D ion trap, a linear ion trap, and a portable ion trap. A system was developed to mix reference compounds with breath for the investigation of the ionization sources as well as for standardization and online quantification of semi-volatile compounds in breath.
DOI 10.1016/j.ijms.2010.10.011
Additional Notes Received 28 August 2010, Revised 8 October 2010, Accepted 8 October 2010, Available online 15 October 2010
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
Organisational Unit(s)
NEBIS System Number 000024690
Source Database ID FORM-1295266194
WOS-000286556900011
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@article{Brchtld2011,
  author = "Berchtold, Christian and Meier, Lukas and Zenobi, Renato",
  title = "{E}valuation of {E}xtractive {E}lectrospray {I}onization and {A}tmospheric {P}ressure {C}hemical {I}onization for the {D}etection of {N}arcotics in {B}reath",
  journal = "International journal of mass spectrometry",
  year = 2011,
  volume = "299",
  number = "2-3",
  pages = "145--150",
  month = jan,
}


E-Citations record created: Mon, 17 Jan 2011, 12:10:08 CET