Simultaneous sampling of volatile and non-volatile analytes in beer for fast fingerprinting by extractive electrospray ionization mass spectrometry

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Author(s) Zhu, Liang, Hu, Zhong, Gamez, Gerardo, Law, Wai Siang, Chen, HuanWen, Yang, ShuiPing, Chingin, Konstantin, Balabin, Roman M., Wang, Rui, Zhang, TingTing, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Simultaneous sampling of volatile and non-volatile analytes in beer for fast fingerprinting by extractive electrospray ionization mass spectrometry
Author(s) Zhu, Liang
Hu, Zhong
Gamez, Gerardo
Law, Wai Siang
Chen, HuanWen
Yang, ShuiPing
Chingin, Konstantin
Balabin, Roman M.
Wang, Rui
Zhang, TingTing
Zenobi, Renato
Journal or Series Title Analytical and bioanalytical chemistry
Volume Number 398
Issue Number 1
Start Page 405
End Page 413
ISSN 1618-2642
1618-2650
Publisher Springer
Publication Place Berlin
Publication Date 2010
Keyword(s) Extractive electrospray ionization
Beer analysis
EESI mechanism
Abstract By gently bubbling nitrogen gas through beer, an effervescent beverage, both volatile and non-volatile compounds can be simultaneously sampled in the form of aerosol. This allows for fast (within seconds) fingerprinting by extractive electrospray ionization mass spectrometry (EESI-MS) in both negative and positive ion mode, without the need for any sample pre-treatment such as degassing and dilution. Trace analytes such as volatile esters (e.g., ethyl acetate and isoamyl acetate), free fatty acids (e.g., caproic acid, caprylic acid, and capric acid), semi/non-volatile organic/inorganic acids (e.g., lactic acid), and various amino acids, commonly present in beer at the low parts per million or at sub-ppm levels, were detected and identified based on tandem MS data. Furthermore, the appearance of solvent cluster ions in the mass spectra gives insight into the sampling and ionization mechanisms: aerosol droplets containing semi/non-volatile substances are thought to be generated via bubble bursting at the surface of the liquid; these neutral aerosol droplets then collide with the charged primary electrospray ionization droplets, followed by analyte extraction, desolvation, ionization, and MS detection. With principal component analysis, several beer samples were successfully differentiated. Therefore, the present study successfully extends the applicability of EESI-MS to the direct analysis of complex liquid samples with high gas content.
DOI 10.1007/s00216-010-3945-8
Additional Notes Received 6 April 2010, Revised 4 June 2010, Accepted 20 June 2010, Published online 20 July 2010
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
Organisational Unit(s)
NEBIS System Number 004239219
Source Database ID WOS-000280807500033
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@article{Zh2010,
  author = "Zhu, Liang and Hu, Zhong and Gamez, Gerardo and Law, Wai Siang and Chen, HuanWen and Yang, ShuiPing and Chingin, Konstantin and Balabin, Roman M. and Wang, Rui and Zhang, TingTing and Zenobi, Renato",
  title = "{S}imultaneous sampling of volatile and non-volatile analytes in beer for fast fingerprinting by extractive electrospray ionization mass spectrometry",
  journal = "Analytical and bioanalytical chemistry",
  year = 2010,
  volume = "398",
  number = "1",
  pages = "405--413",
}


E-Citations record created: Mon, 30 Aug 2010, 09:16:38 CET