On the Mechanism of Extractive Electrospray Ionization

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Author(s) Law, Wai Siang, Wang, Rui, Hu, Bin, Berchtold, Christian, Meier, Lukas, Chen, Huanwen, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title On the Mechanism of Extractive Electrospray Ionization
Author(s) Law, Wai Siang
Wang, Rui
Hu, Bin
Berchtold, Christian
Meier, Lukas
Chen, Huanwen
Zenobi, Renato
Journal or Series Title Analytical chemistry
Volume Number 82
Issue Number 11
Start Page 4494
End Page 4599
ISSN 0003-2700
Publisher American Chemical Society
Publication Place Washington, D.C
Publication Date 2010
Abstract Extractive electrospray ionization (EESI) is a powerful ambient ionization technique that can provide comprehensive mass spectrometric (MS) information on aerosols, complex liquids, or suspensions without any sample pretreatment. An understanding of the EESI mechanism is critical for defining its range of application, the advantages, and limitations of EESI, and for improving its repeatability, sensitivity, and selectivity. However, no systematic study of EESI mechanisms has been conducted so far. In this work, fluorescence studies in the EESI plume using rhodamine 6G and H-acid sodium salt directly demonstrate that liquid-phase interactions occur between charged ESI droplets and neutral sample droplets. Moreover, the effect of the composition of the primary ESI spray and sample spray on signals of the analyte in EESI-MS was investigated systematically. The results show that the analyte signals strongly depend on its solubility in the solvents involved, indicating that selective extraction is the dominant mechanism involved in the EESI process. This mechanistic study provides valuable insights for optimizing the performance of EESI in future applications.
DOI 10.1021/ac100390t
Additional Notes Received 11 February 2010, Accepted 20 April 2010, Publication Date (Web) 5 May 2010
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
Organisational Unit(s)
NEBIS System Number 000005465
Source Database ID FORM-1275394175
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  author = "Law, Wai Siang and Wang, Rui and Hu, Bin and Berchtold, Christian and Meier, Lukas and Chen, Huanwen and Zenobi, Renato",
  title = "{O}n the {M}echanism of {E}xtractive {E}lectrospray {I}onization",
  journal = "Analytical chemistry",
  year = 2010,
  volume = "82",
  number = "11",
  pages = "4494--4599",

E-Citations record created: Tue, 01 Jun 2010, 12:09:38 CET