Aryl hydrocarbon receptor-mediated activity of atmospheric particulate matter from an urban and a rural site in Switzerland

Metadata Label Value
Author(s) Wenger, Daniela, Gerecke, Andreas C., Heeb, Norbert V., Hueglin, Christoph, Seiler, Cornelia, Haag, Regula, Naegeli, Hanspeter, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
Full Text Search SFX for a Full-Text version of this document
Import to Mendeley Log in to provide feedback

Detailed Information

Metadata Field Content
Title Aryl hydrocarbon receptor-mediated activity of atmospheric particulate matter from an urban and a rural site in Switzerland
Author(s) Wenger, Daniela
Gerecke, Andreas C.
Heeb, Norbert V.
Hueglin, Christoph
Seiler, Cornelia
Haag, Regula
Naegeli, Hanspeter
Zenobi, Renato
Journal or Series Title Atmospheric environment
Volume Number 43
Issue Number 22-23
Start Page 3556
End Page 3562
ISSN 1352-2310
0004-6981
Publisher Elsevier
Publication Place Amsterdam
Publication Date 2009
Keyword(s) DR-CALUX
PAH
Air pollution
Particulate matter
PM1
Abstract Atmospheric particulate matter (PM) is an air-suspended mixture of solid and liquid particles that vary in size, shape, and chemical composition. Long-term exposure to elevated concentrations of fine atmospheric particles is considered to pose a health threat to humans and animals. In this context, it has been hypothesized that toxic chemicals such as polycyclic aromatic hydrocarbons (PAHs) play an important role. Some PAHs are known to be carcinogenic and it has been shown that carcinogenic effects of PAHs are mediated by the aryl hydrocarbon receptor (AhR). In this study, PM1 was collected at a rural and an urban traffic site during an intense winter smog period, in which concentration of PM1 often exceeded 50 μg m−3. We applied an in vitro reporter gene assay (DR-CALUX) to detect and quantify PM1-associated chemicals that induce AhR-mediated gene expression. This activity was expressed as CALUX equivalents of 2,3,7,8-tetrachlorodibenzodioxin (PM-TCDD-CEQs). In addition, concentrations of PAHs in the PM1 extracts were determined using gas chromatography/high-resolution mass spectrometry. Concentrations of PM-TCDD-CEQs ranged from 10 to 85 pg m−3 and from 19 to 87 pg m−3 at the urban and rural site, respectively. By the use of known relative potency factors, the measured concentration of a PAH was converted into a PAH-TCDD-CEQ concentration. ΣPAH-TCDD-CEQ and PM-TCDD-CEQ were highly correlated at both sites (r2 = 0.90 and 0.69). The calculated ΣPAH-TCDD-CEQs explain between 2% and 20% of the measured PM-TCDD-CEQs. Benzo[k]fluoranthene was the most important PAH causing approximately 60% of the total ΣPAH-TCDD-CEQ activity. In contrast to NO, CO, PM10, and PM1, the concentration of PM-TCDD-CEQs showed no significant difference between the two sites. No indications were found that road traffic emissions caused elevated concentrations of PM-TCDD-CEQs at the urban traffic site.
DOI 10.1016/j.atmosenv.2009.04.012
Additional Notes Received 15 January 2009, Revised 2 April 2009, Accepted 3 April 2009, Available online 17 April 2009
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
Organisational Unit(s)
NEBIS System Number 002060155
Source Database ID FORM-1275391313
PP-51484
WOS-000267964300014
Description File Name MIME Type Size
No details could be found
There are no links available for this record.
This record has not been viewed during this period

@article{Wngr2009,
  author = "Wenger, Daniela and Gerecke, Andreas C. and Heeb, Norbert V. and Hueglin, Christoph and Seiler, Cornelia and Haag, Regula and Naegeli, Hanspeter and Zenobi, Renato",
  title = "{A}ryl hydrocarbon receptor-mediated activity of atmospheric particulate matter from an urban and a rural site in {S}witzerland",
  journal = "Atmospheric environment",
  year = 2009,
  volume = "43",
  number = "22-23",
  pages = "3556--3562",
}


E-Citations record created: Tue, 01 Jun 2010, 11:21:57 CET