Detection of Diethyl Phthalate in perfumes by extractive electrospray ionization mass spectrometry

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Author(s) Chingin, Konstantin, Chen, Huanwen, Gamez, Gerardo, Zhu, Liang, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Detection of Diethyl Phthalate in perfumes by extractive electrospray ionization mass spectrometry
Author(s) Chingin, Konstantin
Chen, Huanwen
Gamez, Gerardo
Zhu, Liang
Zenobi, Renato
Journal or Series Title Analytical chemistry
Volume Number 81
Issue Number 1
Start Page 123
End Page 129
ISSN 0003-2700
Publisher American Chemical Society
Publication Place Washington, DC
Publication Date 2009
Abstract Recent findings suggest that long-term exposure to diethyl phthalate (DEP), one of the widely used phthalate esters, can lead to serious health problems. Most perfumes contain non-negligible amounts of DEP. Rapid and sensitive detection of DEP in perfumes is thus of increasing importance. A novel procedure based on extractive electrospray ionization mass spectrometry (EESI-MS) has been developed for fast detection and identification of DEP in perfumes without the need for any sample pretreatment. The limit of determination for DEP in perfume was less than 100 ppb using tandem mass spectrometry on a commercial quadrupole time-of-flight mass spectrometer. The dynamic range of this method was about 4 orders of magnitude. A single sample analysis was completed within a few seconds, providing a rapid way to obtain semiquantitative information on the DEP content in perfumes. This study shows that both volatile and nonvolatile analytes (e.g., amino acids) in liquids can be directly sampled by neutral desorption, providing a convenient way for high-throughput screening of target compounds using EESI-MS.
DOI 10.1021/ac801572d
Additional Notes Received 25 July 2008, Accepted 18 November 2008, Publication Date (Web) 8 December 2008
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
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NEBIS System Number 000005465
Source Database ID PP-49092
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  author = "Chingin, Konstantin and Chen, Huanwen and Gamez, Gerardo and Zhu, Liang and Zenobi, Renato",
  title = "{D}etection of {D}iethyl {P}hthalate in perfumes by extractive electrospray ionization mass spectrometry",
  journal = "Analytical chemistry",
  year = 2009,
  volume = "81",
  number = "1",
  pages = "123--129",

E-Citations record created: Fri, 02 Apr 2010, 03:35:27 CET