Real-time, on-line monitoring of organic chemical reactions using extractive electrospray ionization tandem mass spectrometry

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Author(s) Zhu, Liang, Gamez, Gerardo, Chen, Huan Wen, Huang, Hao Xi, Chingin, Konstantin, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Real-time, on-line monitoring of organic chemical reactions using extractive electrospray ionization tandem mass spectrometry
Author(s) Zhu, Liang
Gamez, Gerardo
Chen, Huan Wen
Huang, Hao Xi
Chingin, Konstantin
Zenobi, Renato
Journal or Series Title Rapid communications in mass spectrometry
Volume Number 22
Issue Number 19
Start Page 2993
End Page 2998
ISSN 0951-4198
1097-0231
Publisher Wiley
Publication Place London
Publication Date 2008
Abstract Extractive electrospray ionization mass spectrometry (EESI-MS) for real-time monitoring of organic chemical reactions was demonstrated for a well-established pharmaceutical process reaction and a widely used acetylation reaction in the presence of a nucleophilic catalyst, 4-dimethylaminopyridine (4-DMAP). EESI-MS provides real-time information that allows us to determine the optimum time for terminating the reaction based on the relative intensities of the precursors and products. In addition, tandem mass spectrometric (MS/MS) analysis via EESI-MS permits on-line validation of proposed reaction intermediates. The simplicity and rapid response of EESI-MS make it a valuable technique for on-line characterization and full control of chemical and pharmaceutical reactions, resulting in maximized product yield and minimized environmental costs.
DOI 10.1002/rcm.3700
Additional Notes Received 13 June 2008, Revised 31 July 2008, Accepted 31 July 2008, Published Online 2 September 2008
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
Organisational Unit(s)
NEBIS System Number 000038989
Source Database ID PP-41460
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@article{Zh2008,
  author = "Zhu, Liang and Gamez, Gerardo and Chen, Huan Wen and Huang, Hao Xi and Chingin, Konstantin and Zenobi, Renato",
  title = "{R}eal-time, on-line monitoring of organic chemical reactions using extractive electrospray ionization tandem mass spectrometry",
  journal = "Rapid communications in mass spectrometry",
  year = 2008,
  volume = "22",
  number = "19",
  pages = "2993--2998",
}


E-Citations record created: Thu, 01 Apr 2010, 23:01:39 CET