Towards nanoscale molecular analysis at atmospheric pressure by a near-field laser ablation ion trap/time-of-flight mass spectrometer

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Author(s) Schmitz, Thomas A., Gamez, Gerardo, Setz, Patrick D., Zhu, Liang, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Towards nanoscale molecular analysis at atmospheric pressure by a near-field laser ablation ion trap/time-of-flight mass spectrometer
Author(s) Schmitz, Thomas A.
Gamez, Gerardo
Setz, Patrick D.
Zhu, Liang
Zenobi, Renato
Journal or Series Title Analytical chemistry
Volume Number 80
Issue Number 17
Start Page 6537
End Page 6544
ISSN 0003-2700
1520-6882
Publisher American Chemical Society
Publication Place Washington, DC
Publication Date 2008
Abstract An instrument that combines near-field laser ablation at atmospheric pressure with an ion trap/time-of-flight mass spectrometer was developed. By coupling a UV laser into a fiber tip of a scanning near-field optical microscope, ablation craters much smaller than achievable with conventional laser optics can in principle be obtained. Laser ablation was performed on samples such as DHB, anthracene, and pyrene. Desorbed neutral analytes are transferred from atmospheric pressure to an ion trap, ionized, and stored. After 10 ms, the ions are extracted into a sensitive time-of-flight spectrometer. We demonstrate the feasibility of this unique SNOM-MS instrument for chemical analysis with unprecedented lateral resolution at atmospheric pressure. Spatially resolved molecular analysis with a lateral resolution of 5 mu m (fwhm) and a sensitivity of similar to 60 fmol of solid andiracene is demonstrated, along with topographical analysis with the same instrument. No other technique available today offers this lateral resolution in combination with soft mass spectrometry and the capability of sampling fragile specimens at atmospheric pressure.
DOI 10.1021/ac8005044
Additional Notes Publication Date (Web) 12 July 2008
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
Organisational Unit(s)
NEBIS System Number 000005465
Source Database ID PP-41454
PP-41458
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@article{Schmtz2008,
  author = "Schmitz, Thomas A. and Gamez, Gerardo and Setz, Patrick D. and Zhu, Liang and Zenobi, Renato",
  title = "{T}owards nanoscale molecular analysis at atmospheric pressure by a near-field laser ablation ion trap/time-of-flight mass spectrometer",
  journal = "Analytical chemistry",
  year = 2008,
  volume = "80",
  number = "17",
  pages = "6537--6544",
}


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