Tip-enhanced Raman spectroscopy can see more

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Author(s) Yeo, Boon-Siang, Mädler, Stefanie, Schmid, Thomas, Zhang, Weihua, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Tip-enhanced Raman spectroscopy can see more
Subtitle The case of cytochrome C
Author(s) Yeo, Boon-Siang
Mädler, Stefanie
Schmid, Thomas
Zhang, Weihua
Zenobi, Renato
Journal or Series Title The journal of physical chemistry. C
Volume Number 112
Issue Number 13
Start Page 4867
End Page 4873
ISSN 1932-7447
Publisher American Chemical Society
Publication Place Washington, DC
Publication Date 2008
Abstract The heme protein, cytochrome c (Cc) has been studied using tip-enhanced Raman spectroscopy (TERS). By virtue of its sensitivity and superior spatial resolution, TERS detected both the heme and amino acid vibrational bands of Cc using resonance excitation at 532 nm. This is in contrast to conventional surface-enhanced Raman spectroscopy (SERS) where ensemble information is obtained, leading to the strongest Raman bands obscuring the weaker ones; i.e., only the resonantly enhanced heme bands are observed. Matrix-assisted laser desorption/ionization mass spectrometry supported the interpretation of the Raman data by showing that Cc remains intact on Ag surfaces. This work demonstrates the sensitivity of TERS for analyzing proteins (complete with band assignments) and that a collection of TER spectra gives a more complete description of large biomolecules. The latter is an important advantage usually not found in SERS measurements.
DOI 10.1021/jp709799m
Additional Notes Received: October 7, 2007, In Final Form: December 13, 2007, Publication Date (Web): March 12, 2008
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
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NEBIS System Number 005283485
Source Database ID PP-40954
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  author = "Yeo, Boon-Siang and M{\"{a}}dler, Stefanie and Schmid, Thomas and Zhang, Weihua and Zenobi, Renato",
  title = "{T}ip-enhanced {R}aman spectroscopy can see more: {T}he case of cytochrome {C}",
  journal = "The journal of physical chemistry. C",
  year = 2008,
  volume = "112",
  number = "13",
  pages = "4867--4873",

E-Citations record created: Thu, 01 Apr 2010, 22:43:42 CET