Effects of PPARγ Agonist Pioglitazone on Redox-Sensitive Cellular Signaling in Young Spontaneously Hypertensive Rats

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Author(s) Dovinová, Ima, Barancik, Miroslav, Majzunova, Miroslava, Zorad, Stefan, Gajdosechova, Lucia, Gresová, Linda, Cacanyiova, Sona, Kristek, Frantisek, Balis, Peter, Chan, Julie Y.H.
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Title Effects of PPARγ Agonist Pioglitazone on Redox-Sensitive Cellular Signaling in Young Spontaneously Hypertensive Rats
Author(s) Dovinová, Ima
Barancik, Miroslav
Majzunova, Miroslava
Zorad, Stefan
Gajdosechova, Lucia
Gresová, Linda
Cacanyiova, Sona
Kristek, Frantisek
Balis, Peter
Chan, Julie Y.H.
Description 11 p.
Journal or Series Title PPAR Research
Volume Number 2013
Start Page 541871
ISSN 1687-4757
Publisher Hindawi
Publication Place Cairo
Publication Date 2013
Abstract PPARγ receptor plays an important role in oxidative stress response. Its agonists can influence vascular contractility in experimental hypertension. Our study was focused on the effects of a PPARγ agonist pioglitazone (PIO) on blood pressure regulation, vasoactivity of vessels, and redox-sensitive signaling at the central (brainstem, BS) and peripheral (left ventricle, LV) levels in young prehypertensive rats. 5-week-old SHR were treated either with PIO (10 mg/kg/day, 2 weeks) or with saline using gastric gavage. Administration of PIO significantly slowed down blood pressure increase and improved lipid profile and aortic relaxation after insulin stimulation. A significant increase in PPARγ expression was found only in BS, not in LV. PIO treatment did not influence NOS changes, but had tissue-dependent effect on SOD regulation and increased SOD activity, observed in LV. The treatment with PIO differentially affected also the levels of other intracellular signaling components: Akt kinase increased in the the BS, while β-catenin level was down-regulated in the BS and up-regulated in the LV. We found that the lowering of blood pressure in young SHR can be connected with insulin sensitivity of vessels and that β-catenin and SOD levels are important agents mediating PIO effects in the BS and LV.
DOI 10.1155/2013/541871
Document Type Article
Publication Status Published
Language English
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NEBIS System Number 010200373
Source Database ID FORM-1495024590
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  author = "Dovinov{\'{a}}, Ima and Barancik, Miroslav and Majzunova, Miroslava and Zorad, Stefan and Gajdosechova, Lucia and Gresov{\'{a}}, Linda and Cacanyiova, Sona and Kristek, Frantisek and Balis, Peter and Chan, Julie Y.H.",
  title = "{E}ffects of {P}{P}{A}{R}γ {A}gonist {P}ioglitazone on {R}edox-{S}ensitive {C}ellular {S}ignaling in {Y}oung {S}pontaneously {H}ypertensive {R}ats",
  journal = "PPAR Research",
  year = 2013,
  volume = "2013",
  pages = "541871--",

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