Synthesis and stabilities of peptide-based [1]rotaxanes: molecular grafting onto lasso peptide scaffolds
Open access
Date
2017-04-01Type
- Journal Article
Abstract
The chemical synthesis of peptide-based [1]rotaxanes (lasso peptides) was achieved by [2]rotaxane formation followed by two chemoselective ligation reactions. Our approach enabled incorporation of various peptide sequences into a common rotaxane structure. The synthetic lasso peptides were characterized by NMR, chromatography, and partial degradation by proteases. A linear peptide epitope grafted onto the rotaxane scaffold showed significantly improved proteolytic stability. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000129987Publication status
publishedExternal links
Journal / series
Chemical ScienceVolume
Pages / Article No.
Publisher
Royal Society of ChemistryOrganisational unit
03861 - Bode, Jeffrey W. / Bode, Jeffrey W.
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