Toward faster and higher resolution LA–ICPMS imaging: on the co-evolution of LA cell design and ICPMS instrumentation
Open access
Date
2016-04Type
- Journal Article
Abstract
We describe trends in fast, high resolution elemental imaging by laser ablation–inductively coupled plasma mass spectrometry (LA–ICPMS). Recently developed low dispersion LA cells deliver quantitative transport of ablated aerosols within 10 ms and also provide enhanced sensitivity compared to conventional LA cells because the analyte ion signal becomes less diluted during aerosol transport. When connected to simultaneous ICPMS instruments, these low dispersion LA cells offer a platform for high speed and high lateral resolution shot-resolved LA–ICPMS imaging. Here, we examine the current paradigms of LA–ICPMS imaging and discuss how newly developed LA cell technology combined with simultaneous ICPMS instrumentation is poised to overcome current instrumental limitations to deliver faster, higher resolution elemental imaging. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000112903Publication status
publishedExternal links
Journal / series
Analytical and Bioanalytical ChemistryVolume
Pages / Article No.
Publisher
SpringerSubject
Elemental imaging; ICPMS; Laser ablation; Mass spectrometry; Time-of-flightOrganisational unit
03512 - Günther, Detlef / Günther, Detlef
Funding
624280 - LA-ICPMS: Fast Imaging – Resolution, Sensitivity, and Time (FIRST). (EC)
Notes
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.More
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