Bioprinting Complex Cartilaginous Structures with Clinically Compliant Biomaterials

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Author(s) Kesti, Matti, Eberhardt, Christian, Pagliccia, Guglielmo, Kenkel, David, Grande, Daniel, Boss, Andreas, Zenobi-Wong, Marcy
Publication Type Journal Items, Publication Status: Published
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Title Bioprinting Complex Cartilaginous Structures with Clinically Compliant Biomaterials
Author(s) Kesti, Matti
Eberhardt, Christian
Pagliccia, Guglielmo
Kenkel, David
Grande, Daniel
Boss, Andreas
Zenobi-Wong, Marcy
Journal or Series Title Advanced Functional Materials
Volume Number 25
Issue Number 48
Start Page 7406
End Page 7417
ISSN 1616-301X
1616-3028
Publisher Wiley-VCH
Publication Place Weinheim
Publication Date 2015-12
Keyword(s) Biomedical applications
Hydrogels
Tissue engineering
Abstract Bioprinting is an emerging technology for the fabrication of patient-specific, anatomically complex tissues and organs. A novel bioink for printing cartilage grafts is developed based on two unmodified FDA-compliant polysaccharides, gellan and alginate, combined with the clinical product BioCartilage (cartilage extracellular matrix particles). Cell-friendly physical gelation of the bioink occurs in the presence of cations, which are delivered by co-extrusion of a cation-loaded transient support polymer to stabilize overhanging structures. Rheological properties of the bioink reveal optimal shear thinning and shear recovery properties for high-fidelity bioprinting. Tensile testing of the bioprinted grafts reveals a strong, ductile material. As proof of concept, 3D auricular, nasal, meniscal, and vertebral disk grafts are printed based on computer tomography data or generic 3D models. Grafts after 8 weeks in vitro are scanned using magnetic resonance imaging and histological evaluation is performed. The bioink containing BioCartilage supports proliferation of chondrocytes and, in the presence of transforming growth factor beta-3, supports strong deposition of cartilage matrix proteins. A clinically compliant bioprinting method is presented which yields patient-specific cartilage grafts with good mechanical and biological properties. The versatile method can be used with any type of tissue particles to create tissue-specific and bioactive scaffolds.
DOI 10.1002/adfm.201503423
Additional Notes Published online 19 November 2015
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03949
Organisational Unit(s)
NEBIS System Number 004184794
Source Database ID SCOPUS-84947814951
WOS-000367219400001
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@article{Kst2015,
  author = "Kesti, Matti and Eberhardt, Christian and Pagliccia, Guglielmo and Kenkel, David and Grande, Daniel and Boss, Andreas and Zenobi-Wong, Marcy",
  title = "{B}ioprinting {C}omplex {C}artilaginous {S}tructures with {C}linically {C}ompliant {B}iomaterials",
  journal = "Advanced Functional Materials",
  year = 2015,
  volume = "25",
  number = "48",
  pages = "7406--7417",
  month = dec,
}


E-Citations record created: Tue, 08 Dec 2015, 15:51:12 CET