Nanostructured Pluronic hydrogels as bioinks for 3D bioprinting

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Author(s) Müller, Michael, Becher, Jana, Schnabelrauch, Matthias, Zenobi-Wong, Marcy
Publication Type Journal Items, Publication Status: Published
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Title Nanostructured Pluronic hydrogels as bioinks for 3D bioprinting
Author(s) Müller, Michael
Becher, Jana
Schnabelrauch, Matthias
Zenobi-Wong, Marcy
Description 17 p.
Journal or Series Title Biofabrication
Volume Number 7
Issue Number 3
Start Page 035006
ISSN 1758-5090
Publisher Institute of Physics
Publication Place Bristol
Publication Date 2015
Keyword(s) Bioprinting
Tissue engineering
Thermoresponsive polymer
Abstract Bioprinting is an emerging technology in the field of tissue engineering as it allows the precise positioning of biologically relevant materials in 3D, which more resembles the native tissue in our body than current homogenous, bulk approaches. There is however a lack of materials to be used with this technology and materials such as the block copolymer Pluronic have good printing properties but do not allow long-term cell culture. Here we present an approach called nanostructuring to increase the biocompatibility of Pluronic gels at printable concentrations. By mixing acrylated with unmodified Pluronic F127 it was possible to maintain the excellent printing properties of Pluronic and to create stable gels via UV crosslinking. By subsequent elution of the unmodified Pluronic from the crosslinked network we were able to increase the cell viability of encapsulated chondrocytes at day 14 from 62% for a pure acrylated Pluronic hydrogel to 86% for a nanostructured hydrogel. The mixed Pluronic gels also showed good printability when cells where included in the bioink. The nanostructured gels were, with a compressive modulus of 1.42 kPa, mechanically weak, but we were able to increase the mechanical properties by the addition of methacrylated hyaluronic acid. Our nanostructuring approach enables Pluronic hydrogels to have the desired set of properties in all stages of the bioprinting process.
DOI 10.1088/1758-5090/7/3/035006
Additional Notes Received 31 January 2015, Revised 22 May 2015, Accepted for Publication 9 June 2015, Published 11 August 2015
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03949
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NEBIS System Number 005828698
Source Database ID FORM-1443646916
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  author = "M{\"{u}}ller, Michael and Becher, Jana and Schnabelrauch, Matthias and Zenobi-Wong, Marcy",
  title = "{N}anostructured {P}luronic hydrogels as bioinks for 3{D} bioprinting",
  journal = "Biofabrication",
  year = 2015,
  volume = "7",
  number = "3",
  pages = "035006--",

E-Citations record created: Wed, 30 Sep 2015, 21:02:04 CET