A versatile bioink for three-dimensional printing of cellular scaffolds based on thermally and photo-triggered tandem gelation

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Author(s) Kesti, Matti, Müller, Michael, Becher, Jana, Schnabelrauch, Matthias, D'Este, Matteo, Eglin, David, Zenobi-Wong, Marcy
Publication Type Journal Items, Publication Status: Published
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Title A versatile bioink for three-dimensional printing of cellular scaffolds based on thermally and photo-triggered tandem gelation
Author(s) Kesti, Matti
Müller, Michael
Becher, Jana
Schnabelrauch, Matthias
D'Este, Matteo
Eglin, David
Zenobi-Wong, Marcy
Journal or Series Title Acta Biomaterialia
Volume Number 11
Start Page 162
End Page 172
ISSN 1742-7061
1878-7568
Publisher Elsevier
Publication Place Amsterdam
Publication Date 2015-01
Keyword(s) Bioprinting
HA-pNIPAAM
Thermoresponsive polymer
Cartilage engineering
Abstract Layer-by-layer bioprinting is a logical choice for the fabrication of stratified tissues like articular cartilage. Printing of viable organ replacements, however, is dependent on bioinks with appropriate rheological and cytocompatible properties. In cartilage engineering, photocrosslinkable glycosaminoglycan-based hydrogels are chondrogenic, but alone have generally poor printing properties. By blending the thermoresponsive polymer poly(N-isopropylacrylamide) grafted hyaluronan (HA-pNIPAAM) with methacrylated hyaluronan (HAMA), high-resolution scaffolds with good viability were printed. HA-pNIPAAM provided fast gelation and immediate post-printing structural fidelity, while HAMA ensured long-term mechanical stability upon photocrosslinking. The bioink was evaluated for rheological properties, swelling behavior, printability and biocompatibility of encapsulated bovine chondrocytes. Elution of HA-pNIPAAM from the scaffold was necessary to obtain good viability. HA-pNIPAAM can therefore be used to support Extrusion of a range of biopolymers which undergo tandem gelation, thereby facilitating the printing of cell-laden, stratified cartilage constructs with zonally varying composition and stiffness.
DOI 10.1016/j.actbio.2014.09.033
Additional Notes Received 26 April 2014, Received in revised form 14 August 2014, Accepted 18 September 2014, Available online 23 September 2014
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03949
Organisational Unit(s)
NEBIS System Number 005866783
Source Database ID FORM-1440746121
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@article{Kst2015,
  author = "Kesti, Matti and M{\"{u}}ller, Michael and Becher, Jana and Schnabelrauch, Matthias and D'Este, Matteo and Eglin, David and Zenobi-Wong, Marcy",
  title = "{A} versatile bioink for three-dimensional printing of cellular scaffolds based on thermally and photo-triggered tandem gelation",
  journal = "Acta Biomaterialia",
  year = 2015,
  volume = "11",
  pages = "162--172",
  month = jan,
}


E-Citations record created: Fri, 28 Aug 2015, 07:15:27 CET