Real-Time High-Resolution Tandem Mass Spectrometry Identifies Furan Derivatives in Exhaled Breath

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Author(s) Garcia-Gomez, Diego, Bregy, Lukas, Barrios-Collado, César, Vidal-de-Miguel, Guillermo, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Real-Time High-Resolution Tandem Mass Spectrometry Identifies Furan Derivatives in Exhaled Breath
Author(s) Garcia-Gomez, Diego
Bregy, Lukas
Barrios-Collado, César
Vidal-de-Miguel, Guillermo
Zenobi, Renato
Journal or Series Title Analytical Chemistry
Volume Number 87
Issue Number 13
Start Page 6919
End Page 6924
ISSN 0003-2700
Publisher American Chemical Society
Publication Place Washington, DC
Publication Date 2015-07-07
Abstract The identification of chemical compounds in exhaled human breath is promising in the search for new biomakers of diseases. However, the analytical techniques used nowadays are not capable of achieving a robust identification, especially in real-time analysis. In this work, we show that real-time high-resolution tandem mass spectrometry (HRMS/MS) is suitable for the identification of biomarkers in exhaled breath. Using this approach, we identified a number of furan derivatives, compounds found in the exhalome whose nature and origin are not yet clearly understood. It is also shown that the combination of HRMS/MS with UHPLC allowed not only the identification of the furan derivatives but also the proper separation of their isomeric forms.
DOI 10.1021/acs.analchem.5b01509
Additional Notes Received 22 April 2015, Accepted 8 June 2015, Published online 8 June 2015
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
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NEBIS System Number 000005465
Source Database ID WOS-000357839700073
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  author = "Garcia-Gomez, Diego and Bregy, Lukas and Barrios-Collado, C{\'{e}}sar and Vidal-de-Miguel, Guillermo and Zenobi, Renato",
  title = "{R}eal-{T}ime {H}igh-{R}esolution {T}andem {M}ass {S}pectrometry {I}dentifies {F}uran {D}erivatives in {E}xhaled {B}reath",
  journal = "Analytical Chemistry",
  year = 2015,
  volume = "87",
  number = "13",
  pages = "6919--6924",
  month = jul,

E-Citations record created: Mon, 17 Aug 2015, 09:43:35 CET