Improved analysis of ultra-high molecular mass polystyrenes in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using DCTB matrix and caesium salts

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Author(s) Gabriel, Stefan J., Steinhoff, Robert F., Pabst, Martin, Schwarzinger, Clemens, Zenobi, Renato, Panne, Ulrich, Weidner, Steffen M.
Publication Type Journal Items, Publication Status: Published
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Title Improved analysis of ultra-high molecular mass polystyrenes in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using DCTB matrix and caesium salts
Author(s) Gabriel, Stefan J.
Steinhoff, Robert F.
Pabst, Martin
Schwarzinger, Clemens
Zenobi, Renato
Panne, Ulrich
Weidner, Steffen M.
Journal or Series Title Rapid Communications in Mass Spectrometry (RCM)
Volume Number 29
Issue Number 11
Start Page 1039
End Page 1046
ISSN 0951-4198
1097-0231
Publisher Wiley
Publication Place London
Publication Date 2015-06
Abstract RATIONALE:
The ionization of polystyrenes in matrix-assisted laser desorption/ionization mass spectrometry (MALDIMS) is typically achieved by the use of silver salts. Since silver salts can cause severe problems, such as cluster formation, fragmentation of polymer chains and end group cleavage, their substitution by alkali salts is highly desirable.

METHODS:
The influence of various cations (Ag+, Cs+ and Rb+) on the MALDI process of polystyrene (PS) mixtures and high mass polystyrenes was examined. The sample preparation was kept as straightforward as possible. Consequently, no recrystallization or other cleaning procedures were applied.

RESULTS:
The investigation of a polystyrene mixture showed that higher molecular polystyrenes could be more easily ionized using caesium, rather than rubidium or silver salts. In combination with the use of DCTB as matrix a highmass polymer analysis could be achieved, which was demonstrated by the detection of a 1.1 MDa PS.

CONCLUSIONS:
A fast, simple and robust MALDI sample preparation method for the analysis of ultra-high molecular weight polystyrenes based on the use of DCTB and caesium salts has been presented. The suitability of the presented method has been validated by using different mass spectrometers and detectors.
DOI 10.1002/rcm.7197
Additional Notes Received 15 January 2015, Revised 9 March 2015, Accepted 9 March 2015, Published online 20 April 2015
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
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NEBIS System Number 000038989
Source Database ID WOS-000354566900007
SCOPUS-84938509861
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@article{Gbrl2015,
  author = "Gabriel, Stefan J. and Steinhoff, Robert F. and Pabst, Martin and Schwarzinger, Clemens and Zenobi, Renato and Panne, Ulrich and Weidner, Steffen M.",
  title = "{I}mproved analysis of ultra-high molecular mass polystyrenes in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using {D}{C}{T}{B} matrix and caesium salts",
  journal = "Rapid Communications in Mass Spectrometry (RCM)",
  year = 2015,
  volume = "29",
  number = "11",
  pages = "1039--1046",
  month = jun,
}


E-Citations record created: Mon, 08 Jun 2015, 07:41:30 CET