Identification of 2-alkenals, 4-hydroxy-2-alkenals, and 4-hydroxy-2,6-alkadienals in exhaled breath condensate by UHPLC-HRMS and in breath by real-time HRMS

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Author(s) García-Gómez, Diego, Martinez-Lozano Sinues, Pablo, Barrios-Collado, Cesar, Vidal-de-Miguel, Guillermo, Gaugg, Martin, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Identification of 2-alkenals, 4-hydroxy-2-alkenals, and 4-hydroxy-2,6-alkadienals in exhaled breath condensate by UHPLC-HRMS and in breath by real-time HRMS
Author(s) García-Gómez, Diego
Martinez-Lozano Sinues, Pablo
Barrios-Collado, Cesar
Vidal-de-Miguel, Guillermo
Gaugg, Martin
Zenobi, Renato
Journal or Series Title analytical chemistry
Volume Number 87
Issue Number 5
Start Page 3087
End Page 3093
ISSN 0003-2700
1520-6882
Publisher American Chemical Society
Publication Place Washington, D.C
Publication Date 2015-03-03
Abstract In recent years, breath analysis in real time has become a noninvasive alternative for the diagnosis of diseases and for molecular fingerprinting of exhaled breath. However, the techniques used lack the capabilities for proper identification of the compounds found in the exhalome. Here, we report the use of UHPLC-HRMS as a tool for the identification of several aldehydes (2-alkenals, 4-hydroxy-2-alkenals, and 4-hydroxy-2,6-alkadienals), biomarkers of lipid peroxidation, in exhaled breath condensate of three healthy subjects (N = 3). Some of the aldehydes studied have never been identified before. Their robust identification is based on retention times, on the generation of fragmentation trees from tandem mass spectra, and on the comparison of these parameters with standards. We also show that the identified compounds can be analyzed and confirmed by MS/MS in breath in real time and, therefore, they could be used as biomarkers for the rapid and noninvasive diagnosis of related diseases.
DOI 10.1021/ac504796p
Additional Notes Received 23 December 2014, Accepted 3 February 2015, Published 3 February 2015
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
Organisational Unit(s)
NEBIS System Number 000005465
Source Database ID SCOPUS-84924212937
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@article{Grc2015,
  author = "Garc{\'{i}}a-G{\'{o}}mez, Diego and Martinez-Lozano Sinues, Pablo and Barrios-Collado, Cesar and Vidal-de-Miguel, Guillermo and Gaugg, Martin and Zenobi, Renato",
  title = "{I}dentification of 2-alkenals, 4-hydroxy-2-alkenals, and 4-hydroxy-2,6-alkadienals in exhaled breath condensate by {U}{H}{P}{L}{C}-{H}{R}{M}{S} and in breath by real-time {H}{R}{M}{S}",
  journal = "analytical chemistry",
  year = 2015,
  volume = "87",
  number = "5",
  pages = "3087--3093",
  month = mar,
}


E-Citations record created: Tue, 17 Mar 2015, 14:05:47 CET