Manipulation of charge states of biopolymer ions by atmospheric pressure ion/molecule reactions implemented in an extractive electrospray ionization source

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Author(s) Chen, Huanwen, Touboul, David, Jecklin, Matthias C., Zheng, Jian, Luo, Mingbiao, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Manipulation of charge states of biopolymer ions by atmospheric pressure ion/molecule reactions implemented in an extractive electrospray ionization source
Author(s) Chen, Huanwen
Touboul, David
Jecklin, Matthias C.
Zheng, Jian
Luo, Mingbiao
Zenobi, Renato
Journal or Series Title European journal of mass spectrometry
Volume Number 13
Issue Number 4
Start Page 273
End Page 279
ISSN 1469-0667
Publisher IM Publications
Publication Place Chichester
Publication Date 2007
Keyword(s) atmospheric pressure ion/molecule reaction
charge state manipulation
biopolymer ions
spectral congestion
proton stripping
Abstract A home-made extractive electrospray ionization source is coupled to an linear quadrupole ion trap mass spectrometer to investigate ion/molecule reactions of biopolymers at ambient pressure. Multiply charged biopolymers such as peptides and proteins generated in an electrospray are easily reduced to a low charge state by the atmospheric pressure ion/molecule reactions occurring between the multiply charged ions and a strong basic reagent sprayed in neutral form into the electrospray plume. The charge state of the biopolymer ions can be manipulated by controlling the amount of the basic reagent. The production of biopolymer ions with low charge states results in a substantial improvement of sensitivity and reduced spectral congestion in ESI-MS. This is of importance for biopolymer mixture analysis and could have promising applications in proteomics.
DOI 10.1255/ejms.879
Additional Notes Received 4 May 2007, Revised 24 August 2007, Accepted 24 August 2007
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
Organisational Unit(s)
Source Database ID PP-34149
WOS-000251012000004
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@article{Chn2007,
  author = "Chen, Huanwen and Touboul, David and Jecklin, Matthias C. and Zheng, Jian and Luo, Mingbiao and Zenobi, Renato",
  title = "{M}anipulation of charge states of biopolymer ions by atmospheric pressure ion/molecule reactions implemented in an extractive electrospray ionization source",
  journal = "European journal of mass spectrometry",
  year = 2007,
  volume = "13",
  number = "4",
  pages = "273--279",
}


E-Citations record created: Thu, 01 Apr 2010, 18:35:01 CET