Rapid In Vivo Fingerprinting of Nonvolatile Compounds in Breath by Extractive Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometry

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Author(s) Chen, Huanwen, Wortmann, Arno, Zhang, Weihua, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Rapid In Vivo Fingerprinting of Nonvolatile Compounds in Breath by Extractive Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometry
Author(s) Chen, Huanwen
Wortmann, Arno
Zhang, Weihua
Zenobi, Renato
Journal or Series Title Angewandte Chemie. International edition
Volume Number 46
Issue Number 4
Start Page 580
End Page 583
ISSN 1433-7851
0570-0833
1521-3773
Publisher Wiley-VCH
Publication Place Weinheim
Publication Date 2007
Keyword(s) analytical methods
breath analysis
ion-molecule reactions
mass spectrometry
medicinal chemistry
Abstract A blow-by-blow account: Extractive electrospray ionization (EESI) quadrupole TOF (QTOF) mass spectrometry has been established with a commercial instrument without hardware modification for the rapid analysis of breath without sample pretreatment (see picture). Sulfur-containing compounds can be selectively detected by using silver cationization in the EESI source - a method of interest for in vivo metabolic studies and clinical diagnosis.
DOI 10.1002/anie.200602942
Additional Notes Received 21 July 2006, Revised 7 September 2006, Published Online 2 November 2006
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
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NEBIS System Number 000033716
Source Database ID PP-34134
WOS-000243609200019
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@article{Chn2007,
  author = "Chen, Huanwen and Wortmann, Arno and Zhang, Weihua and Zenobi, Renato",
  title = "{R}apid {I}n {V}ivo {F}ingerprinting of {N}onvolatile {C}ompounds in {B}reath by {E}xtractive {E}lectrospray {I}onization {Q}uadrupole {T}ime-of-{F}light {M}ass {S}pectrometry",
  journal = "Angewandte Chemie. International edition",
  year = 2007,
  volume = "46",
  number = "4",
  pages = "580--583",
}


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