Real-time monitoring of exhaled drugs by mass spectrometry

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Author(s) Berchtold, Christian, Bosilkovska, Marija, Daali, Youssef, Walder, Bernhard, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Real-time monitoring of exhaled drugs by mass spectrometry
Author(s) Berchtold, Christian
Bosilkovska, Marija
Daali, Youssef
Walder, Bernhard
Zenobi, Renato
Journal or Series Title Mass spectrometry reviews
Volume Number 33
Issue Number 5
Start Page 394
End Page 413
ISSN 0277-7037
Publisher Wiley
Publication Place New York, NY
Publication Date 2014-09
Keyword(s) Real-time analysis
Drug analysis
Breath analysis
Ambient mass spectrometry
Abstract Future individualized patient treatment will need tools to monitor the dose and effects of administrated drugs. Mass spectrometry may become the method of choice to monitor drugs in real time by analyzing exhaled breath. This review describes the monitoring of exhaled drugs in real time by mass spectrometry. The biological background as well as the relevant physical properties of exhaled drugs are delineated. The feasibility of detecting and monitoring exhaled drugs is discussed in several examples. The mass spectrometric tools that are currently available to analyze breath in real time are reviewed. The technical needs and state of the art for on-site measurements by mass spectrometry are also discussed in detail. Off-line methods, which give support and are an important source of information for real-time measurements, are also discussed. Finally, some examples of drugs that have already been successfully detected in exhaled breath, including propofol, fentanyl, methadone, nicotine, and valproic acid are presented. Real-time monitoring of exhaled drugs by mass spectrometry is a relatively new field, which is still in the early stages of development. New technologies promise substantial benefit for future patient monitoring and treatment.
DOI 10.1002/mas.21393
Additional Notes Article first published online 22 November 2013
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
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NEBIS System Number 000015310
Source Database ID WOS-000340469100004
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  author = "Berchtold, Christian and Bosilkovska, Marija and Daali, Youssef and Walder, Bernhard and Zenobi, Renato",
  title = "{R}eal-time monitoring of exhaled drugs by mass spectrometry",
  journal = "Mass spectrometry reviews",
  year = 2014,
  volume = "33",
  number = "5",
  pages = "394--413",
  month = sep,

E-Citations record created: Mon, 15 Sep 2014, 08:18:17 CET