Real-time breath analysis with active capillary plasma ionization-ambient mass spectrometry

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Author(s) Bregy, Lukas, Sinues, Pablo M.L., Nudnova, Maryia M., Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Real-time breath analysis with active capillary plasma ionization-ambient mass spectrometry
Author(s) Bregy, Lukas
Sinues, Pablo M.L.
Nudnova, Maryia M.
Zenobi, Renato
Description 8 p.
Journal or Series Title Journal of breath research
Volume Number 8
Issue Number 2
Start Page 027102
ISSN 1752-7155
Publisher Institute of Physics
Publication Place Bristol
Publication Date 2014-06
Keyword(s) Medical physics
Biological physics
Chemical physics and physical chemistry
Abstract On-line analysis of exhaled human breath is a growing area in analytical science, for applications such as fast and non-invasive medical diagnosis and monitoring. In this work, we present a novel approach based on ambient ionization of compounds in breath and subsequent real-time mass spectrometric analysis. We introduce a plasma ionization source for this purpose, which has no need for additional gases, is very small, and is easily interfaced with virtually any commercial atmospheric pressure ionization mass spectrometer (API-MS) without major modifications. If an API-MS instrument exists in a laboratory, the cost to implement this technology is only around is an element of 500, far less than the investment for a specialized mass spectrometric system designed for volatile organic compounds (VOCs) analysis. In this proof-of-principle study we were able to measure mass spectra of exhaled human breath and found these to be comparable to spectra obtained with other electrospray-based methods. We detected over 100 VOCs, including relevant metabolites like fatty acids, with molecular weights extending up to 340 Da. In addition, we were able to monitor the time-dependent evolution of the peaks and show the enhancement of the metabolism after a meal. We conclude that this approach may complement current methods to analyze breath or other types of vapors, offering an affordable option to upgrade any pre-existing API-MS to a real-time breath analyzer.
DOI 10.1088/1752-7155/8/2/027102
Additional Notes Received 27 September 2013, Revised 11 November 2013, Accepted for publication 27 November 2013, Published 28 March 2014
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
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NEBIS System Number 005428423
Source Database ID WOS-000337353100005
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  author = "Bregy, Lukas and Sinues, Pablo M.L. and Nudnova, Maryia M. and Zenobi, Renato",
  title = "{R}eal-time breath analysis with active capillary plasma ionization-ambient mass spectrometry",
  journal = "Journal of breath research",
  year = 2014,
  volume = "8",
  number = "2",
  pages = "027102--",
  month = jun,

E-Citations record created: Mon, 21 Jul 2014, 10:52:50 CET