Fingerprinting breast cancer vs. normal mammary cells by mass spectrometric analysis of volatiles

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Author(s) He, Jingjing, Sinues, Pablo M.L., Hollmén, Maija, Li, Xue, Detmar, Michael, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Fingerprinting breast cancer vs. normal mammary cells by mass spectrometric analysis of volatiles
Author(s) He, Jingjing
Sinues, Pablo M.L.
Hollmén, Maija
Li, Xue
Detmar, Michael
Zenobi, Renato
Description 6 p.
Journal or Series Title Scientific Reports
Volume Number 4
Start Page 5196
ISSN 2045-2322
Publisher Nature Publishing Group
Publication Place London
Publication Date 2014-06
Abstract There is increasing interest in the development of noninvasive diagnostic methods for early cancer detection, to improve the survival rate and quality of life of cancer patients. Identification of volatile metabolic compounds may provide an approach for noninvasive early diagnosis of malignant diseases. Here we analyzed the volatile metabolic signature of human breast cancer cell lines versus normal human mammary cells. Volatile compounds in the headspace of conditioned culture medium were directly fingerprinted by secondary electrospray ionization-mass spectrometry. The mass spectra were subsequently treated statistically to identify discriminating features between normal vs. cancerous cell types. We were able to classify different samples by using feature selection followed by principal component analysis (PCA). Additionally, high-resolution mass spectrometry allowed us to propose their chemical structures for some of the most discriminating molecules. We conclude that cancerous cells can release a characteristic odor whose constituents may be used as disease markers.
DOI 10.1038/srep05196
Additional Notes Received 20 December 2013, Accepted 23 April 2014, Published 6 June 2014
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03683
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NEBIS System Number 006751867
Source Database ID SCOPUS-84902143802
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  author = "He, Jingjing and Sinues, Pablo M.L. and Hollm{\'{e}}n, Maija and Li, Xue and Detmar, Michael and Zenobi, Renato",
  title = "{F}ingerprinting breast cancer vs. normal mammary cells by mass spectrometric analysis of volatiles",
  journal = "Scientific Reports",
  year = 2014,
  volume = "4",
  pages = "5196--",
  month = jun,

E-Citations record created: Tue, 24 Jun 2014, 07:14:40 CET