High-Mass MALDI-MS Using Ion Conversion Dynode Detectors

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Author(s) Weidmann, Simon, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title High-Mass MALDI-MS Using Ion Conversion Dynode Detectors
Subtitle Influence of the Conversion Voltage on Sensitivity and Spectral Quality
Author(s) Weidmann, Simon
Zenobi, Renato
Journal or Series Title Journal of the American Society for Mass Spectrometry
Volume Number 25
Issue Number 6
Start Page 950
End Page 954
ISSN 1044-0305
1879-1123
Publisher Springer
Publication Place New York
Publication Date 2014-06
Keyword(s) MALDI-ToF-MS
High-mass protein analysis
Ion conversion dynode
Sensitivity
Resolution
Abstract With the development of special ion conversion dynode (ICD) detectors for high-mass matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), the mass-to-charge ratio is no longer a limiting factor. Although these detectors have been successfully used in the past, there is lack of understanding of the basic processes in the detector. We present a systematic study to investigate the performance of such an ICD detector and separate the contributions of the MALDI process from the ones of the ion-to-secondary ion and the secondary ion-to-electron conversions. The performance was evaluated as a function of the voltages applied to the conversion dynodes and the sample amount utilized, and we found that the detector reflects the MALDI process correctly: limitations such as sensitivity or deviations from the expected signal intensity ratios originate from the MALDI process itself and not from the detector.
DOI 10.1007/s13361-014-0867-2
Additional Notes Received 5 December 2013, Revised 7 February 2014, Accepted 7 February 2014, Published Online 29 March 2014
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
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NEBIS System Number 000541631
Source Database ID WOS-000336025800008
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@article{Wdmnn2014,
  author = "Weidmann, Simon and Zenobi, Renato",
  title = "{H}igh-{M}ass {M}{A}{L}{D}{I}-{M}{S} {U}sing {I}on {C}onversion {D}ynode {D}etectors: {I}nfluence of the {C}onversion {V}oltage on {S}ensitivity and {S}pectral {Q}uality",
  journal = "Journal of the American Society for Mass Spectrometry",
  year = 2014,
  volume = "25",
  number = "6",
  pages = "950--954",
  month = jun,
}


E-Citations record created: Mon, 16 Jun 2014, 07:07:35 CET