Breath Analysis in Real Time by Mass Spectrometry in Chronic Obstructive Pulmonary Disease

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Author(s) Sinues, Pablo Martinez-Lozano, Meier, Lukas, Berchtold, Christian, Ivanov, Mark, Sievi, Noriane, Camen, Giovanni, Kohler, Malcolm, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Breath Analysis in Real Time by Mass Spectrometry in Chronic Obstructive Pulmonary Disease
Author(s) Sinues, Pablo Martinez-Lozano
Meier, Lukas
Berchtold, Christian
Ivanov, Mark
Sievi, Noriane
Camen, Giovanni
Kohler, Malcolm
Zenobi, Renato
Journal or Series Title Respiration
Volume Number 87
Issue Number 4
Start Page 301
End Page 310
ISSN 0025-7931
Publisher Karger
Publication Place Basel
Publication Date 2014
Keyword(s) Breath test
Chronic obstructive pulmonary disease
Exhaled biomarkers
Abstract Background: It has been suggested that exhaled breath contains relevant information on health status. Objectives: We hypothesized that a novel mass spectrometry (MS) technique to analyze breath in real time could be useful to differentiate breathprints from chronic obstructive pulmonary disease (COPD) patients and controls (smokers and nonsmokers). Methods: We studied 61 participants including 25 COPD patients [Global Initiative for Obstructive Lung Disease (GOLD) stages I-IV], 25 nonsmoking controls and 11 smoking controls. We analyzed their breath by MS in real time. Raw mass spectra were then processed and statistically analyzed. Results: A panel of discriminating mass-spectral features was identified for COPD (all stages; n = 25) versus healthy nonsmokers (n = 25), COPD (all stages; n = 25) versus healthy smokers (n = 11) and mild COPD (GOLD stages I/ II; n = 13) versus severe COPD (GOLD stages III/ IV; n = 12). A blind classification (i.e. leave-one-out cross validation) resulted in 96% sensitivity and 72.7% specificity (COPD vs. hsmoking controls), 88% sensitivity and 92% specificity (COPD vs. nonsmoking controls) and 92.3% sensitivity and 83.3% specificity (GOLD I/II vs. GOLD III/IV). Acetone and indole were identified as two of the discriminating exhaled molecules. Conclusions: We conclude that real-time MS may be a useful technique to analyze and characterize the metabolome of exhaled breath. The acquisition of breathprints in a rapid manner may be valuable to support COPD diagnosis and to gain insight into the disease.
DOI 10.1159/000357785
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
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NEBIS System Number 001006108
Source Database ID WOS-000334297300007
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  author = "Sinues, Pablo Martinez-Lozano and Meier, Lukas and Berchtold, Christian and Ivanov, Mark and Sievi, Noriane and Camen, Giovanni and Kohler, Malcolm and Zenobi, Renato",
  title = "{B}reath {A}nalysis in {R}eal {T}ime by {M}ass {S}pectrometry in {C}hronic {O}bstructive {P}ulmonary {D}isease",
  journal = "Respiration",
  year = 2014,
  volume = "87",
  number = "4",
  pages = "301--310",

E-Citations record created: Mon, 26 May 2014, 09:56:21 CET