Amyloid-hydroxyapatite bone biomimetic composites

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Author(s) Li, Chaoxu, Born, Anne-Kathrin, Schweizer, Thomas, Zenobi-Wong, Marcy, Cerruti, Marta, Mezzenga, Raffaele
Publication Type Journal Items, Publication Status: Published
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Title Amyloid-hydroxyapatite bone biomimetic composites
Author(s) Li, Chaoxu
Born, Anne-Kathrin
Schweizer, Thomas
Zenobi-Wong, Marcy
Cerruti, Marta
Mezzenga, Raffaele
Journal or Series Title Advanced materials
Volume Number 26
Issue Number 20
Start Page 3207
End Page 3212
ISSN 0935-9648
1521-4095
Publisher Weinheim
Publication Place Wiley-VCH
Publication Date 2014-03-18
Keyword(s) Amyloid fibrils
Biomimetic materials
Bone-mimetic nanocomposites
Hydroxyapatite
Osteoblast
Abstract A “bottom up” strategy is proposed to synthesize high aspect ratio hydroxyapatite (and brushite) platelets, and combine them with amyloid fibrils into layered hybrid nanocomposites. Their hierarchical structure, despite the differences from natural bone, confers to the nanocomposites a density and elastic modulus matching those of cancellous bone. Evidence of good adhesion and spreading of human trabecular bone-derived pre-osteoblasts cells on these nanocomposites is provided.
DOI 10.1002/adma.201306198
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03857
03437
03359
03949
Organisational Unit(s)
NEBIS System Number 000504408
Source Database ID SCOPUS-84895912391
WOS-000336999800002
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@article{L2014,
  author = "Li, Chaoxu and Born, Anne-Kathrin and Schweizer, Thomas and Zenobi-Wong, Marcy and Cerruti, Marta and Mezzenga, Raffaele",
  title = "{A}myloid-hydroxyapatite bone biomimetic composites",
  journal = "Advanced materials",
  year = 2014,
  volume = "26",
  number = "20",
  pages = "3207--3212",
  month = mar,
}


E-Citations record created: Tue, 25 Mar 2014, 06:47:48 CET