Analysis of the Exhalome: A Diagnostic Tool of the Future

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Author(s) Martinez-Lozano Sinues, Pablo, Zenobi, Renato, Kohler, Malcolm
Publication Type Journal Items, Publication Status: Published
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Title Analysis of the Exhalome: A Diagnostic Tool of the Future
Author(s) Martinez-Lozano Sinues, Pablo
Zenobi, Renato
Kohler, Malcolm
Journal or Series Title Chest
Volume Number 144
Issue Number 3
Start Page 746
End Page 749
ISSN 0012-3692
Publisher American College of Chest Physicians
Publication Place Northbrook, IL
Publication Date 2013-08
Abstract Investigations on breath analysis have provided preliminary data on its potential in the noninvasive diagnosis of lung diseases. Although the conventional comparisons of exhaled breath in study populations (ie, diseased vs healthy) may help to identify patients with various lung diseases, we believe that the analysis of exhaled breath holds promise beyond this scenario. On the basis of preliminary findings, we hypothesize that breath analysis (1) could be applied not only to identify patients with lung disease but also to better phenotype healthy subjects at risk and patients with a particular disease, which is in-line with current efforts toward individualized medicine; (2) could be useful in estimating internal body time to determine the optimal time of drug administration, thereby maximizing drug activity and reducing toxicity (chronopharmacology); and (3) could be applied to monitor drugs or drug metabolites, thus, enhancing adherence to prescribed medications and enabling studies on pharmacokinetics.
DOI 10.1378/chest.13-1106
Document Type Article
Publication Status Published
Language English
NEBIS System Number 004337438
Source Database ID WOS-000326161700010
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  author = "Martinez-Lozano Sinues, Pablo and Zenobi, Renato and Kohler, Malcolm",
  title = "{A}nalysis of the {E}xhalome: {A} {D}iagnostic {T}ool of the {F}uture",
  journal = "Chest",
  year = 2013,
  volume = "144",
  number = "3",
  pages = "746--749",
  month = aug,

E-Citations record created: Mon, 25 Nov 2013, 07:27:36 CET