P45 Forms a Complex with FADD and Promotes Neuronal Cell Survival Following Spinal Cord Injury
Abstract
Fas-associated death domain (DD) adaptor (FADD), a member of the DD superfamily, contains both a DD and a death effector domain (DED) that are important in mediating FAS ligand-induced apoptotic signaling. P45 is a unique member of the DD superfamily in that it has a domain with sequence and structural characteristics of both DD and DED. We show that p45 forms a complex with FADD and diminishes Fas-FADD mediated death signaling. The DED of FADD is required for the complex formation with p45. Following spinal cord injury, transgenic mice over-expressing p45 exhibit increased neuronal survival, decreased retraction of corticospinal tract fibers and improved functional recovery. Understanding p45-mediated cellular and molecular mechanisms may provide insights into facilitating nerve regeneration in humans. Show more
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https://doi.org/10.3929/ethz-b-000073961Publication status
publishedExternal links
Journal / series
PLoS ONEVolume
Pages / Article No.
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PLOSOrganisational unit
03782 - Riek, Roland / Riek, Roland
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