Methods for Molecular Nanoanalysis

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Author(s) Schmid, Thomas, Schmitz, Thomas A., Setz, Patrick D., Yeo, Boon-Siang, Zhang, Weihua, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Methods for Molecular Nanoanalysis
Author(s) Schmid, Thomas
Schmitz, Thomas A.
Setz, Patrick D.
Yeo, Boon-Siang
Zhang, Weihua
Zenobi, Renato
Journal or Series Title Chimia
Volume Number 60
Issue Number 11
Start Page 783
End Page 788
ISSN 0009-4293
Publisher Swiss Chemical Society
Publication Place Bern
Publication Date 2006-11
Keyword(s) Atmospheric pressure nanoscale laser ablation mass
Scanning near-field optical microscopy (SNOM)
Tip-enhanced Raman scattering (TERS)
Abstract This contribution reviews methods based on scanning probe microscopy for molecular analysis and identification on a length scale of 20-200 nm. Aperture scanning near-field optical microscopy (SNOM) was initially developed in our group for chemical analysis and imaging using fluorescence and Raman spectroscopies, with a resolution beyond the optical diffraction limit. In recent years, tip-enhanced Raman spectroscopy was developed into an analytical tool capable of a spatial resolution less than 50 nm and, using the 'gap' mode of operation, the promise for single molecule sensitivity and even higher spatial resolution. Aperture SNOM with pulsed laser irradiation can be used for nanoscale laser ablation. With an interface to a very sensitive mass spectrometer, this provides a platform for nanoscale mass spectrometry using atmospheric pressure sampling. The preparation of fiber tips for aperture SNOM as well as metallized a FM tips and etched metal wires for aperture less SNOM applications is reviewed. Finally, applications for the chemical analysis of thin molecular films and of biological samples are presented.
DOI 10.2533/chimia.2006.783
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
Organisational Unit(s)
NEBIS System Number 000000830
Source Database ID PP-25379
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  author = "Schmid, Thomas and Schmitz, Thomas A. and Setz, Patrick D. and Yeo, Boon-Siang and Zhang, Weihua and Zenobi, Renato",
  title = "{M}ethods for {M}olecular {N}anoanalysis",
  journal = "Chimia",
  year = 2006,
  volume = "60",
  number = "11",
  pages = "783--788",
  month = nov,

E-Citations record created: Thu, 01 Apr 2010, 16:30:15 CET