Development and Characterization of a Capillary Gap Sampler as New Microfluidic Device for Fast and Direct Analysis of Low Sample Amounts by ESI-MS

Metadata Label Value
Author(s) Neu, Volker, Steiner, Roger, Müller, Stephan, Fattinger, Christof, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
Full Text Search SFX for a Full-Text version of this document
Import to Mendeley Log in to provide feedback

Detailed Information

Metadata Field Content
Title Development and Characterization of a Capillary Gap Sampler as New Microfluidic Device for Fast and Direct Analysis of Low Sample Amounts by ESI-MS
Author(s) Neu, Volker
Steiner, Roger
Müller, Stephan
Fattinger, Christof
Zenobi, Renato
Journal or Series Title Analytical Chemistry
Volume Number 85
Issue Number 9
Start Page 4628
End Page 4635
ISSN 0003-2700
1520-6882
Publisher American Chemical Society
Publication Place Washington, D.C
Publication Date 2013-05
Abstract Direct hyphenation of miniaturized sampling devices to electrospray ionization-mass spectrometry (ESI-MS) is attractive because ESI-MS is compatible with microfluidics and allows comprehensive sample analysis, yielding information that is orthogonal to that available from optical methods. We present a "capillary gap sampler" as a platform for directly connecting microfluidics to mu-ESI-MS. The sampler was designed to be robust, light and compact, and to allow precise and fast liquid handling. Sample introduction in the range of a few nanoliters is performed via an open liquid bridge as a new rnicrofluidic element This allows minimum contact of the sample with system surfaces during the infusion process. The system shows good performance characteristics such as symmetrical peak shapes, low sample carryover (below 1%), and total injection cycle times of less than 15 s. This new device thus has the potential for rapid analysis of biomedical and pharmaceutical samples with limited sample amounts in a high-throughput mode.
DOI 10.1021/ac400186t
Additional Notes Received 28 January 2013, Accepted 9 April 2013
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
Organisational Unit(s)
NEBIS System Number 000005465
Source Database ID WOS-000318756100060
Description File Name MIME Type Size
No details could be found
There are no links available for this record.
This record has not been viewed during this period

@article{N2013,
  author = "Neu, Volker and Steiner, Roger and M{\"{u}}ller, Stephan and Fattinger, Christof and Zenobi, Renato",
  title = "{D}evelopment and {C}haracterization of a {C}apillary {G}ap {S}ampler as {N}ew {M}icrofluidic {D}evice for {F}ast and {D}irect {A}nalysis of {L}ow {S}ample {A}mounts by {E}{S}{I}-{M}{S}",
  journal = "Analytical Chemistry",
  year = 2013,
  volume = "85",
  number = "9",
  pages = "4628--4635",
  month = may,
}


E-Citations record created: Mon, 01 Jul 2013, 07:54:51 CET