Human Breath Analysis May Support the Existence of Individual Metabolic Phenotypes

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Author(s) Sinues, Pablo Martinez-Lozano, Kohler, Malcolm, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Human Breath Analysis May Support the Existence of Individual Metabolic Phenotypes
Author(s) Sinues, Pablo Martinez-Lozano
Kohler, Malcolm
Zenobi, Renato
Description 5 p.
Journal or Series Title Plos One
Volume Number 8
Issue Number 4
Start Page e59909
ISSN 1932-6203
Publisher Public Library of Science
Publication Place Lawrence, Kan.
Publication Date 2013-04
Abstract The metabolic phenotype varies widely due to external factors such as diet and gut microbiome composition, among others. Despite these temporal fluctuations, urine metabolite profiling studies have suggested that there are highly individual phenotypes that persist over extended periods of time. This hypothesis was tested by analyzing the exhaled breath of a group of subjects during nine days by mass spectrometry. Consistent with previous metabolomic studies based on urine, we conclude that individual signatures of breath composition exist. The confirmation of the existence of stable and specific breathprints may contribute to strengthen the inclusion of breath as a biofluid of choice in metabolomic studies. In addition, the fact that the method is rapid and totally non-invasive, yet individualized profiles can be tracked, makes it an appealing approach.
DOI 10.1371/journal.pone.0059909
Additional Notes Received 29 October 2012, Accepted 22 February 2013, Published 3 April 2013
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
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NEBIS System Number 006206116
Source Database ID WOS-000318840100034
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  author = "Sinues, Pablo Martinez-Lozano and Kohler, Malcolm and Zenobi, Renato",
  title = "{H}uman {B}reath {A}nalysis {M}ay {S}upport the {E}xistence of {I}ndividual {M}etabolic {P}henotypes",
  journal = "Plos One",
  year = 2013,
  volume = "8",
  number = "4",
  pages = "e59909--",
  month = apr,

E-Citations record created: Mon, 01 Jul 2013, 07:42:21 CET