Use of Polyetheretherketone as a Material for Solid Phase Extraction of Hydroxylated Metabolites of Polycyclic Aromatic Hydrocarbons in Human Urine

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Author(s) Li, Xue, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Use of Polyetheretherketone as a Material for Solid Phase Extraction of Hydroxylated Metabolites of Polycyclic Aromatic Hydrocarbons in Human Urine
Author(s) Li, Xue
Zenobi, Renato
Journal or Series Title Analytical chemistry
Volume Number 85
Issue Number 7
Start Page 3526
End Page 3531
ISSN 0003-2700
1520-6882
Publisher American Chemical Society
Publication Place Washington, DC
Publication Date 2013-04-02
Abstract In this study, a novel application of polyetheretherketone (PEEK) tubing for solid phase extraction (SPE) of urinary hydroxylated metabolites of polycyclic aromatic hydrocarbons (OH-PAHs) is presented. The use of PEEK tubing for extracting nine OH-PAHs (2-5 rings) from different matrixes (e.g., urine, acid/enzymatic hydrolysis solution) was demonstrated; a facile method for fast (<2 min) quantification of urinary 1-hydroxypyrene (1-OHPyr) was also developed by the use of PEEK tubing extraction coupled to electrospray ionization tandem mass spectrometry (ESI-MS/MS). Although no optimization was performed for the extraction process, a limit of detection (LOD) as low as 0.01 mu g L-1 was obtained, and the ratio of signal intensity of 1-OHPyr to that of 1-OHPyr-d9 (internal standard) was linearly related with the 1-OHPyr concentration over the range of 0.05-5.00 mu g L-1 (R-2 = 0.9995). Satisfactory recoveries (87-91%) were achieved, and less than 2 min was required to carry out the whole analytical procedure including sample pretreatment and mass spectrometric detection. In a biomonitoring study, the PEEK tubing extraction based method was successfully applied to the quantification of 1-OHPyr in eight human urine samples, further confirming the potential of PEEK tubing for SPE of organic compounds.
DOI 10.1021/ac303402s
Additional Notes Received 23 November 2012, Accepted 4 March 2013, Accepted 5 March 2013, Published online 5 March 2013
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
Organisational Unit(s)
NEBIS System Number 000005465
Source Database ID WOS-000317173200013
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@article{L2013,
  author = "Li, Xue and Zenobi, Renato",
  title = "{U}se of {P}olyetheretherketone as a {M}aterial for {S}olid {P}hase {E}xtraction of {H}ydroxylated {M}etabolites of {P}olycyclic {A}romatic {H}ydrocarbons in {H}uman {U}rine",
  journal = "Analytical chemistry",
  year = 2013,
  volume = "85",
  number = "7",
  pages = "3526--3531",
  month = apr,
}


E-Citations record created: Tue, 21 May 2013, 08:17:11 CET