In situ detection of gamma-hydroxybutyrate and gamma-butyrolactone in drinks by secondary electrospray ionization

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Author(s) Berchtold, Christian, Schmid, Stefan, Meier, Lukas, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title In situ detection of gamma-hydroxybutyrate and gamma-butyrolactone in drinks by secondary electrospray ionization
Author(s) Berchtold, Christian
Schmid, Stefan
Meier, Lukas
Zenobi, Renato
Journal or Series Title Analytical methods
Volume Number 5
Issue Number 4
Start Page 844
End Page 850
ISSN 1759-9660
1759-9679
Publisher Royal Society of Chemistry
Publication Place Cambridge, UK
Publication Date 2013
Abstract gamma-Hydroxybutyrate (GHB) and gamma-butyrolactone (GBL) are used as "date rape drugs" since they cause catalepsy and memory loss. A new application of secondary electrospray ionization (SESI) mass spectrometry for in situ detection of GHB and GBL in drinks and body fluids is introduced. Different mass spectrometers were compared, including a portable, miniaturized ion trap, a semi mobile bench-top ion trap, and a quadrupole time-of-flight instrument. Direct ionization of GHB and GBL from the headspace of drinks was shown, and the suitability for on-site measurements was tested. Several matrices including various drinks as well as body fluids such as urine and saliva were analyzed. SESI provides a robust, reliable, fast, and efficient ionization method, which is largely independent of the mass spectrometer and the matrix used. The detection limits for GHB and GBL in drinks were found to be always below 0.5 g L-1, which is sufficient to identify them in beverages (a dose of about 2 g L-1 is commonly used). 8 mg L-1 GHB were detectable in urine, which suffices to identify an intoxicated individual. Overall, GHB and GBL can be detected in drinks and small leftovers of drinks as well as in body fluids at concentration levels that are of practical relevance. With a mobile MS instrument, this method could be applied as a diagnostic as well as a preventive on-site method.
DOI 10.1039/C2AY26009C
Additional Notes Received 7 Setpember 2012, Accepted 1 December 2012
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
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NEBIS System Number 005863296
Source Database ID WOS-000314423700003
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@article{Brchtld2013,
  author = "Berchtold, Christian and Schmid, Stefan and Meier, Lukas and Zenobi, Renato",
  title = "{I}n situ detection of gamma-hydroxybutyrate and gamma-butyrolactone in drinks by secondary electrospray ionization",
  journal = "Analytical methods",
  year = 2013,
  volume = "5",
  number = "4",
  pages = "844--850",
}


E-Citations record created: Mon, 11 Mar 2013, 08:32:12 CET