# Ion Mobility Spectrometry Coupled to Laser-Induced Fluorescence

Author(s) Frankevich, Vladimir, Sinues, Pablo Martinez-Lozano, Barylyuk, Konstant, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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## Detailed Information

Title Ion Mobility Spectrometry Coupled to Laser-Induced Fluorescence
Sinues, Pablo Martinez-Lozano
Barylyuk, Konstant
Zenobi, Renato
Journal or Series Title Analytical chemistry
Volume Number 85
Issue Number 1
Start Page 39
End Page 43
ISSN 0003-2700
1520-6882
Publisher American Chemical Society
Publication Place Washington, D.C
Publication Date 2013-01
Abstract We report on interfacing a differential mobility analyzer (DMA) with laser-induced fluorescence (LIF) to simultaneously retrieve two-dimensional information on the electrical mobility and fluorescence spectroscopy of gas-phase ions. The fact that the separation of ions within DMA takes place in space rather than in time allows for the continuous selection of ion beams within a narrow range of mobilities that are further analyzed by LIF. Combination of DMA with LIF is simple and robust. It allows one to detect fluorescence from specified ions, including clusters, which would not survive in a mass spectrometer. Complex mixtures of fluorescent compounds can be separated by the DMA and studied by LIF. LIF is a sensitive technique and useful in the study of molecular interactions. DMA with LIF detection can be used for studies of gas-phase fluorescence of small molecules such as different dyes and their conjugates. This unique instrument combination may also provide a powerful platform for probing fluorescent proteins in the gas phase, which is of great fundamental interest for better understanding of their physical and chemical properties. In the present work, we have studied the gas-phase laser-induced fluorescence of mobility-selected rhodamine 6G ions.
DOI 10.1021/ac303137e
Additional Notes Just accepted manuscript 30 November 2012, Received 27 October 2012, Accepted 30 November 2012
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
Organisational Unit(s)
NEBIS System Number 000005465
Source Database ID WOS-000313156500009
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@article{Frnkvch2013,
author = "Frankevich, Vladimir and Sinues, Pablo Martinez-Lozano and Barylyuk, Konstant and Zenobi, Renato",
title = "{I}on {M}obility {S}pectrometry {C}oupled to {L}aser-{I}nduced {F}luorescence",
journal = "Analytical chemistry",
year = 2013,
volume = "85",
number = "1",
pages = "39--43",
month = jan,
}


E-Citations record created: Mon, 04 Mar 2013, 11:52:23 CET