Monitoring Diurnal Changes in Exhaled Human Breath

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Author(s) Sinues, Pablo Martinez-Lozano, Kohler, Malcolm, Zenobi, Renato
Publication Type Journal Items, Publication Status: Published
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Title Monitoring Diurnal Changes in Exhaled Human Breath
Author(s) Sinues, Pablo Martinez-Lozano
Kohler, Malcolm
Zenobi, Renato
Journal or Series Title Analytical chemistry
Volume Number 85
Issue Number 1
Start Page 369
End Page 373
ISSN 0003-2700
Publisher American Chemical Society
Publication Place Washington, D.C
Publication Date 2013
Abstract The development of noninvasive analytical techniques is of interest to the field of chronobiology, in order to reveal the human metabolome that seems to show temporal patterns and to predict internal body time. We report on the real-time mass spectrometric analysis of human breath as a potential method to be used in this field. The breath of 12 subjects was analyzed during 9 days by secondary electrospray ionization-mass spectrometry (SESI-MS). The samples were collected during four time slots: morning (8:00-11:00), before lunch (11:00-13:00), after lunch (13:00-15:00), and late afternoon (15:00-18:00). A total of 203 mass spectra were statistically analyzed. Univariate analysis revealed a number of features with a marked temporal behavior. Principal component analysis/canonical analysis showed a clear temporal evolution of the breath patterns. A blind cross-validation yielded 84% of correct classifications of the time slot at which the breath samples were collected. We conclude that this approach seems to have potential for the investigation of biological clocks, including the description of internal body time, which may have important implications for the timing of pharmacotherapy.
DOI 10.1021/ac3029097
Additional Notes Just accepted manuscript 30 November 2012, Received 6 October 2012, Accepted 30 November 2012
Document Type Article
Publication Status Published
Language English
Assigned Organisational Unit(s) 03430
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NEBIS System Number 000005465
Source Database ID WOS-000313156500055
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  author = "Sinues, Pablo Martinez-Lozano and Kohler, Malcolm and Zenobi, Renato",
  title = "{M}onitoring {D}iurnal {C}hanges in {E}xhaled {H}uman {B}reath",
  journal = "Analytical chemistry",
  year = 2013,
  volume = "85",
  number = "1",
  pages = "369--373",

E-Citations record created: Mon, 04 Mar 2013, 11:49:34 CET