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1. Angiotensinogen and angiotensin-converting enzyme mRNA decrease and AT1 receptor mRNA and protein increase in epididymal fat tissue accompany age-induced elevation of adiposity and reductions in expression of GLUT4 and peroxisome proliferator-activated receptor (PPARγ)

Krskova, K., Filipcik, P., Zilka, N., Olszanecki, R., Korbut, R., Gajdosechova, L. and Zorad, Stefan (2011)

Elevated adiposity is one of the accompanying features of increased age in humans and animals. Angiotensin II (Ang II) is considered as growth promoting peptide to be involved in hypertrophic enlargement of adipose tissue. However, systemic renin-angiotensin system (RAS) seems to...


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2. Differential regulation of oxytocin receptor in various adipose tissue depots and skeletal muscle types in obese zucker rats

Gajdosechova, Lucia, Krskova, Katarina, Olszanecki, Rafał and Zorad, Stefan (2015)

Multifunctional peptide oxytocin currently undergoes intensive research due to its proposed anti-obesity properties. Until now, little is known about regulation of oxytocin receptor in metabolically active tissues in obesity. The aim of the present study was to measure expression...


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3. Effects of PPARγ Agonist Pioglitazone on Redox-Sensitive Cellular Signaling in Young Spontaneously Hypertensive Rats

Dovinová, Ima, Barancik, Miroslav, Majzunova, Miroslava, Zorad, Stefan, Gajdosechova, Lucia, Gresová, Linda, Cacanyiova, Sona, Kristek, Frantisek, Balis, Peter and Chan, Julie Y.H. (2013)

PPARγ receptor plays an important role in oxidative stress response. Its agonists can influence vascular contractility in experimental hypertension. Our study was focused on the effects of a PPARγ agonist pioglitazone (PIO) on blood pressure regulation, vasoactivity of vessels,...


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4. Hypooxytocinaemia in obese Zucker rats relates to oxytocin degradation in liver and adipose tissue

Gajdosechova, Lucia, Krskova, Katarina, Segarra, Ana B., Spolcova, Andrea, Suski, Maciej, Olszanecki, Rafal and Zorad, Stefan (2014)

The metabolic action of oxytocin has recently been intensively studied to assess the ability of the peptide to regulate energy homeostasis. Despite the obvious weight-reducing effect of oxytocin observed in experimental studies, plasma oxytocin levels were found to be unchanged or...


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5. Melatoninc reduces cardiac remodeling and improves survival in rats with isoproterenol-induced heart failure

Simko, Fedor, Bednarova, Kristina Repova, Krajcirovicova, Kristina, Hrenak, Jaroslav, Celec, Peter, Kamodyova, Natalia, Gajdosechova, Lucia, Zorad, Stefan and Adamcova, Michaela (2014)

Melatonin was previously shown to reduce blood pressure and left ventricular (LV) remodeling in several models of experimental heart damage. This study investigated whether melatonin prevents LV remodeling and improves survival in isoproterenol-induced heart failure. In the first...


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